Document Detail


In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.
MedLine Citation:
PMID:  23292682     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The molecular mechanisms that control how progenitors generate distinct subtypes of neurons, and how undifferentiated neurons acquire their specific identity during corticogenesis, are increasingly understood. However, whether postmitotic neurons can change their identity at late stages of differentiation remains unknown. To study this question, we developed an electrochemical in vivo gene delivery method to rapidly manipulate gene expression specifically in postmitotic neurons. Using this approach, we found that the molecular identity, morphology, physiology and functional input-output connectivity of layer 4 mouse spiny neurons could be specifically reprogrammed during the first postnatal week by ectopic expression of the layer 5B output neuron-specific transcription factor Fezf2. These findings reveal a high degree of plasticity in the identity of postmitotic neocortical neurons and provide a proof of principle for postnatal re-engineering of specific neural microcircuits in vivo.
Authors:
Andres De la Rossa; Camilla Bellone; Bruno Golding; Ilaria Vitali; Jonathan Moss; Nicolas Toni; Christian Lüscher; Denis Jabaudon
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-06
Journal Detail:
Title:  Nature neuroscience     Volume:  -     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland. [2].
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