| In vivo release of dopamine and its metabolites following a direct infusion of L-dopa into the caudate nucleus of awake, freely behaving rats using a push-pull cannula. | |
MedLine Citation:
|
PMID: 3122126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In vivo release of dopamine (DA) and its metabolites were determined following a direct infusion of 3,4-dihydroxyphenylalanine (L-DOPA) through a push-pull cannula in the caudate nucleus of unanesthetized, freely behaving rats. L-DOPA infusions increased the release of DA and dihydroxyphenylacetic acid (DOPAC) beginning with 10(-5) M L-DOPA, while homovanillic acid (HVA) was released consistently only following 10(-3) M L-DOPA. Maximal release of DA preceded that of DOPAC which preceded that of HVA. No salient changes in 5-hydroxyindoleacetic acid or behavior were observed following any L-DOPA dose. |
Authors:
|
D E Dluzen; V D Ramirez |
Related Documents
:
|
3516476 - Uremic encephalopathy: an updating. 7532076 - Microbore high-performance liquid chromatographic method for the measurement of dopamin... 2473856 - Developmental changes of serotonin and 5-hydroxyindoleacetic acid levels in specific re... 3314696 - Pharmacokinetics and bacteriological efficacy of ticarcillin-clavulanic acid (timentin)... 6470366 - Decomposition of leukotriene c4. 6884696 - Sialoglycopeptides obtained from a transplantable rat colorectal adenocarcinoma: a comp... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neuroscience letters Volume: 82 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1987 Nov |
Date Detail:
|
Created Date: 1988-02-17 Completed Date: 1988-02-17 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 29-34 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Biophysics, University of Illinois at Urbana-Champaign 61801. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3,4-Dihydroxyphenylacetic Acid
/
metabolism Animals Behavior, Animal / drug effects Caudate Nucleus / drug effects, metabolism* Dihydroxyphenylalanine / pharmacology* Dopamine / metabolism* Dose-Response Relationship, Drug Female Homovanillic Acid / metabolism Rats Reaction Time |
| Grant Support | |
ID/Acronym/Agency:
|
HD 14625/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 63-84-3/Dihydroxyphenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Innervation of thyrotropin-releasing hormone-containing neurons in the bullfrog pars intermedia.
Next Document: A light and electron microscopic level analysis of calcitonin gene-related peptide (CGRP) in the spi...