Document Detail

In vivo release of dopamine and its metabolites following a direct infusion of L-dopa into the caudate nucleus of awake, freely behaving rats using a push-pull cannula.
MedLine Citation:
PMID:  3122126     Owner:  NLM     Status:  MEDLINE    
In vivo release of dopamine (DA) and its metabolites were determined following a direct infusion of 3,4-dihydroxyphenylalanine (L-DOPA) through a push-pull cannula in the caudate nucleus of unanesthetized, freely behaving rats. L-DOPA infusions increased the release of DA and dihydroxyphenylacetic acid (DOPAC) beginning with 10(-5) M L-DOPA, while homovanillic acid (HVA) was released consistently only following 10(-3) M L-DOPA. Maximal release of DA preceded that of DOPAC which preceded that of HVA. No salient changes in 5-hydroxyindoleacetic acid or behavior were observed following any L-DOPA dose.
D E Dluzen; V D Ramirez
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  82     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-02-17     Completed Date:  1988-02-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  29-34     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Illinois at Urbana-Champaign 61801.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Behavior, Animal / drug effects
Caudate Nucleus / drug effects,  metabolism*
Dihydroxyphenylalanine / pharmacology*
Dopamine / metabolism*
Dose-Response Relationship, Drug
Homovanillic Acid / metabolism
Reaction Time
Grant Support
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 63-84-3/Dihydroxyphenylalanine

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