| In vivo release by vagal stimulation of L-[3H] glutamic acid in the nucleus tractus solitarius preloaded with L-[3H] glutamine. | |
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MedLine Citation:
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PMID: 6143597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In anesthetized and paralyzed rats, using a push-pull perfusion technique, we examined the effect of bilateral vagal stimulation on the release of L-[3H] glutamic acid (L- [3H] Glu) from the nucleus tractus solitarius (NTS), after preloading the tissue either with L-[3H] Glu or L-[3H] glutamine (L- [3H] Gln). Vagal stimulation sufficient to produce a maximum fall of arterial pressure (AP) evoked release of L- [3H] Glu from the NTS when the tissue was preloaded with either 3H-Glu or 3H-Gln, and of D-[3H] aspartic acid (D-[3H] Asp) when this stable Glu analogue was used to preloaded with either 3H-Glu or 3H-Gln, and of D-[3H] precursor L-Gln is a good marker of the releasable pool of L-Glu in vivo and are consistent with the hypothesis that L-[3H] Glu is a neurotransmitter in the NTS, mediating the vasodepressor response from cardiopulmonary mechanoreceptors. |
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Authors:
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A R Granata; A F Sved; D J Reis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research bulletin Volume: 12 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-06-01 Completed Date: 1984-06-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Afferent Pathways
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physiology Animals Autoradiography Electric Stimulation Glutamates / secretion* Glutamic Acid Glutamine / metabolism* Medulla Oblongata / physiology* Perfusion Rats Rats, Inbred Strains Tritium / diagnostic use Vagus Nerve / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL 18974/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 10028-17-8/Tritium; 56-85-9/Glutamine; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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