Document Detail


In vivo regulation of lipolysis in humans.
MedLine Citation:
PMID:  8169522     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acids are important oxidative fuel for liver, kidney, skeletal muscle, and myocardium. There has been much interest in the role of fatty acids in the pathogenesis of non-insulin-dependent diabetes because they compete with glucose for oxygen and inhibit whole body glucose disposal via the 'Randle cycle,' Control of lipolysis in adipose tissue determines systemic fatty acid supply. A wide range of hormones and other substances have been recognized as regulators of lipolysis, but insulin and catecholamines appear to be the most important. The regulation of lipolysis, in most circumstances, provides a supply of lipid fuel exceeding the rate of lipid oxidation, requiring reesterification to triglyceride of surplus circulating free fatty acids. Thus, free fatty acid supply is usually not matched to the demand for lipid oxidation, and there is no known mechanism for accurately sensing such demand. This lax regulation may be disadvantageous in conditions such as aging, stress, obesity, and diabetes, where the antilipolytic effect of insulin is impaired and lipolysis is therefore increased. In these conditions, the surfeit of fatty acid may impair glucoregulation. In addition, the excess lipolysis may induce hypertriglyceridemia (via increased very low density lipoprotein production) and thus contribute to atherogenesis. Considerable additional research is needed in order to fully understand both normal lipolytic regulation and the abnormalities of lipolysis which accompany pathological conditions.
Authors:
S W Coppack; M D Jensen; J M Miles
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of lipid research     Volume:  35     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-01     Completed Date:  1994-06-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  177-93     Citation Subset:  IM    
Affiliation:
Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Diabetes Mellitus / metabolism
Fatty Acids / metabolism
Humans
Lipolysis / physiology*
Liver / metabolism
Muscles / metabolism
Obesity / metabolism
Grant Support
ID/Acronym/Agency:
DK-26989/DK/NIDDK NIH HHS; DK-38092/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Primary malignant melanoma of the pharynx.
Next Document:  Mouse apolipoprotein J: characterization of a gene implicated in atherosclerosis.