| In vivo regulation of hepatic lipase activity and mRNA levels by diets which modify cholesterol influx to the liver. | |
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MedLine Citation:
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PMID: 8117745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to assess whether diets enriched in cholesterol, sodium cholate and drugs known to modify liver cholesterol biosynthesis can modulate hepatic lipase (H-TGL) expression and activity in vivo. Female lean Zucker rats, known to be good responders to cholesterol, were fed for 7 days with a control C diet or the C diet supplemented (w/w) with either 2% cholesterol, 0.5% sodium cholate, 2% cholestyramine or simvastatin (0.1%) added to the cholestyramine diet or given by gavage (10 mg/rat) for 3 days. H-TGL activity decreased by 34% with cholesterol, and by 27% when both cholesterol and cholate were administered to the rats. Under these conditions, H-TGL mRNA decreased by 34% and 87%, respectively. The sharp decrease in H-TGL expression was associated with a strong increase in cholesteryl ester in total liver and in the liver microsome fraction. H-TGL activity decreased by 33% with cholestyramine and the mRNA level decreased by 47%. Simvastatin lowered H-TGL activity by 55% when added to the cholestyramine diet, probably because of a reduction in food intake. When administrated by gavage, simvastatin increased both the H-TGL activity (by 28%) and mRNA (by 23%). These variations may be linked to the availability of mevalonate-derived sterol and non-sterol products. |
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Authors:
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F Benhizia; D Lagrange; M I Malewiak; S Griglio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1211 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-04-07 Completed Date: 1994-04-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 181-8 Citation Subset: IM |
Affiliation:
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Laboratoire de Recherches sur la Physiopathologie de la Nutrition, INSERM U 177, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Cholesterol / metabolism* Cholesterol, Dietary / administration & dosage, pharmacology* Cholestyramine Resin / administration & dosage, pharmacology Cholic Acid Cholic Acids / administration & dosage, pharmacology Diet* Female Hydroxymethylglutaryl CoA Reductases / metabolism Lipase / genetics, metabolism* Lipid Metabolism Lipids / blood Liver / drug effects, enzymology*, metabolism Lovastatin / administration & dosage, analogs & derivatives, pharmacology RNA, Messenger / metabolism* Rats Rats, Zucker Simvastatin |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary; 0/Cholic Acids; 0/Lipids; 0/RNA, Messenger; 11041-12-6/Cholestyramine Resin; 57-88-5/Cholesterol; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin; 81-25-4/Cholic Acid; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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