Document Detail

In vivo real-time endocytoscopic visualization of blood flow in rectal microvasculature.
MedLine Citation:
PMID:  18543138     Owner:  NLM     Status:  MEDLINE    
Endocytoscopy (ECS) is a new technology that enables endoscopists to visualize gastrointestinal mucosa at the cellular level. This reported case demonstrates the ability to visualize real-time blood flow utilizing ECS. Methylene blue dye was sprayed onto normal rectal mucosa during a routine screening colonoscopy of an asymptomatic patient. High-magnification views of colonic mucosa revealed normal mucosal cellular structure and microvasculature with normal flow of red blood cells. Individual red blood cells were seen circulating through the arterioles. Epithelial colonocytes appeared to be organized in a hexagonal pattern around crypts with borders demarcated by microvasculature. ECS can provide high-magnification views of the gastrointestinal mucosa including microvasculature in real time. This establishes possibilities for future in vivo research in areas such as cancer biology, angiogenesis, and inflammatory bowel disease.
B M Yan; J Van Dam
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endoscopy     Volume:  40     ISSN:  1438-8812     ISO Abbreviation:  Endoscopy     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  534-6     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California 94305, USA.
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MeSH Terms
Blood Flow Velocity
Colonoscopy / methods*
Image Enhancement / methods
Intestinal Mucosa / blood supply,  pathology
Methylene Blue / diagnostic use
Microcirculation / physiology
Middle Aged
Rectal Neoplasms / prevention & control*
Rectum / blood supply*,  pathology
Regional Blood Flow / physiology
Sensitivity and Specificity
Reg. No./Substance:
61-73-4/Methylene Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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