| In vivo real-time endocytoscopic visualization of blood flow in rectal microvasculature. | |
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MedLine Citation:
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PMID: 18543138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endocytoscopy (ECS) is a new technology that enables endoscopists to visualize gastrointestinal mucosa at the cellular level. This reported case demonstrates the ability to visualize real-time blood flow utilizing ECS. Methylene blue dye was sprayed onto normal rectal mucosa during a routine screening colonoscopy of an asymptomatic patient. High-magnification views of colonic mucosa revealed normal mucosal cellular structure and microvasculature with normal flow of red blood cells. Individual red blood cells were seen circulating through the arterioles. Epithelial colonocytes appeared to be organized in a hexagonal pattern around crypts with borders demarcated by microvasculature. ECS can provide high-magnification views of the gastrointestinal mucosa including microvasculature in real time. This establishes possibilities for future in vivo research in areas such as cancer biology, angiogenesis, and inflammatory bowel disease. |
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Authors:
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B M Yan; J Van Dam |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endoscopy Volume: 40 ISSN: 1438-8812 ISO Abbreviation: Endoscopy Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-10 Completed Date: 2008-08-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0215166 Medline TA: Endoscopy Country: Germany |
Other Details:
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Languages: eng Pagination: 534-6 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California 94305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Colonoscopes Colonoscopy / methods* Humans Image Enhancement / methods Intestinal Mucosa / blood supply, pathology Male Methylene Blue / diagnostic use Microcirculation / physiology Middle Aged Rectal Neoplasms / prevention & control* Rectum / blood supply*, pathology Regional Blood Flow / physiology Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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61-73-4/Methylene Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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