| In vivo quantification of muscle damage in dogs after general anaesthesia with halothane and propofol. | |
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MedLine Citation:
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PMID: 9444639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Muscle damage in dogs anaesthetised with halothane and propofol was quantified by measurement of the area under the curve of plasma creatine kinase (CK) versus time. Plasma CK remained unchanged during anaesthesia for two and a half and five hours. Following halothane anaesthesia of dogs (resting on one side directly on the surgical table or on cushions, and with or without rotation of the body every 30 minutes), plasma CK was elevated in some animals to 10,000 U/litre by the 12th hour (baseline value < or = 100 u/litre), whereas it remained almost unchanged in other animals. Plasma CK then returned to reference values on day 2 or 3. The mean equivalent of muscle damaged ranged from 0.6 to 0.9 g/kg bodyweight. No muscle damage could be demonstrated in animals anaesthetised with propofol. It is therefore concluded that plasma CK should not be used as a diagnostic aid following halothane anaesthesia because of false positives due to the halothane anaesthesia itself and that propofol is best suited for the investigation of muscle damage due to surgical procedures. |
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Authors:
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B M Aktas; P Vinclair; A Autefage; H P Lefebvre; P L Toutain; J P Braun |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of small animal practice Volume: 38 ISSN: 0022-4510 ISO Abbreviation: J Small Anim Pract Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-02-26 Completed Date: 1998-02-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0165053 Medline TA: J Small Anim Pract Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 565-9 Citation Subset: IM |
Affiliation:
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Département des Sciences Biologiques et Fonctionnelles et URA-INRA Physiopathologie et Toxicologie Expérimentales, Ecole Nationale Vétérinaire, Toulouse, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General
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adverse effects,
veterinary* Anesthetics, Inhalation / adverse effects*, pharmacology Anesthetics, Intravenous / adverse effects*, pharmacology Animals Body Weight / physiology Creatine Kinase / blood Dogs / blood, physiology* Female Halothane / adverse effects*, pharmacology Male Muscle, Skeletal / drug effects*, pathology, physiopathology Propofol / adverse effects*, pharmacology Reference Values Surgical Procedures, Operative / veterinary Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 151-67-7/Halothane; 2078-54-8/Propofol; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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