| In vivo quantification of murine aortic cyclic strain, motion, and curvature: implications for abdominal aortic aneurysm growth. | |
| | |
MedLine Citation:
|
PMID: 20882615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To develop methods to quantify cyclic strain, motion, and curvature of the murine abdominal aorta in vivo. MATERIALS AND METHODS: C57BL/6J and apoE(-/-) mice underwent three-dimensional (3D) time-of-flight MR angiography to position cardiac-gated 2D slices at four locations along the abdominal aorta where circumferential cyclic strain and lumen centroid motion were calculated. From the 3D data, a centerline through the aorta was created to quantify geometric curvature at 0.1-mm intervals. Medial elastin content was quantified with histology postmortem. The location and shape of abdominal aortic aneurysms (AAAs), created from angiotensin II infusion, were evaluated qualitatively. RESULTS: Strain waveforms were similar at all locations and between groups. Centroid motion was significantly larger and more leftward above the renal vessels than below (P < 0.05). Maximum geometric curvature occurred slightly proximal to the right renal artery. Elastin content was similar around the circumference of the vessel. AAAs developed in the same location as the maximum curvature and grew in the same direction as vessel curvature and motion. CONCLUSION: The methods presented provide temporally and spatially resolved data quantifying murine aortic motion and curvature in vivo. This noninvasive methodology will allow serial quantification of how these parameters influence the location and direction of AAA growth. |
| | |
Authors:
|
Craig J Goergen; Kyla N Barr; Diem T Huynh; Jeffrey R Eastham-Anderson; Gilwoo Choi; Maj Hedehus; Ronald L Dalman; Andrew J Connolly; Charles A Taylor; Philip S Tsao; Joan M Greve |
Related Documents
:
|
717895 - Preoperative aortography before abdominal aortic aneurysmectomy? 454025 - Abdominal aortic aneurysms: diagnostic review and new technique. 15090715 - Total detachment of cardiac myxoma causing saddle embolization and mimicking aortic dis... 15227125 - Combined coronary artery bypass graft and abdominal aortic aneurysmectomy. 23513005 - Prevention of arterial graft spasm in rats using a vasodilator-eluting biodegradable na... 20534425 - Intraoperative angiography after coronary bypass grafting in a patient presenting with ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-30 Completed Date: 2011-02-02 Revised Date: 2012-04-27 |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 847-58 Citation Subset: IM |
Affiliation:
|
Department of Bioengineering, Stanford University, Stanford, California 94305-5431, USA. cgoergen@stanford.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
metabolism Animals Aorta, Abdominal / physiopathology* Aortic Aneurysm, Abdominal / physiopathology* Apolipoproteins E / genetics Elastin / metabolism Genotype Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods Male Mice Mice, Inbred C57BL Mice, Transgenic Motion Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
1 P50 HL 83800-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins E; 11128-99-7/Angiotensin II; 9007-58-3/Elastin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuropathological differences between rats and mice after spinal cord injury.
Next Document: Percent infarct mapping for delayed contrast enhancement magnetic resonance imaging to quantify myoc...