Document Detail

In vivo quantification of murine aortic cyclic strain, motion, and curvature: implications for abdominal aortic aneurysm growth.
MedLine Citation:
PMID:  20882615     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To develop methods to quantify cyclic strain, motion, and curvature of the murine abdominal aorta in vivo.
MATERIALS AND METHODS: C57BL/6J and apoE(-/-) mice underwent three-dimensional (3D) time-of-flight MR angiography to position cardiac-gated 2D slices at four locations along the abdominal aorta where circumferential cyclic strain and lumen centroid motion were calculated. From the 3D data, a centerline through the aorta was created to quantify geometric curvature at 0.1-mm intervals. Medial elastin content was quantified with histology postmortem. The location and shape of abdominal aortic aneurysms (AAAs), created from angiotensin II infusion, were evaluated qualitatively.
RESULTS: Strain waveforms were similar at all locations and between groups. Centroid motion was significantly larger and more leftward above the renal vessels than below (P < 0.05). Maximum geometric curvature occurred slightly proximal to the right renal artery. Elastin content was similar around the circumference of the vessel. AAAs developed in the same location as the maximum curvature and grew in the same direction as vessel curvature and motion.
CONCLUSION: The methods presented provide temporally and spatially resolved data quantifying murine aortic motion and curvature in vivo. This noninvasive methodology will allow serial quantification of how these parameters influence the location and direction of AAA growth.
Craig J Goergen; Kyla N Barr; Diem T Huynh; Jeffrey R Eastham-Anderson; Gilwoo Choi; Maj Hedehus; Ronald L Dalman; Andrew J Connolly; Charles A Taylor; Philip S Tsao; Joan M Greve
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  32     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2011-02-02     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  847-58     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / metabolism
Aorta, Abdominal / physiopathology*
Aortic Aneurysm, Abdominal / physiopathology*
Apolipoproteins E / genetics
Elastin / metabolism
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods
Mice, Inbred C57BL
Mice, Transgenic
Time Factors
Grant Support
1 P50 HL 83800-04/HL/NHLBI NIH HHS; P50 HL083800/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Apolipoproteins E; 11128-99-7/Angiotensin II; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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