| In vivo proton magnetic resonance spectroscopic examination of benzodiazepine action in humans. | |
| | |
MedLine Citation:
|
PMID: 21036017 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
In an examination of the effect of benzodiazepines on brain chemistry, 44 healthy controls underwent a short echo-time proton magnetic resonance spectroscopy ((1)H MRS) session after induced sedation with intravenous midazolam (0.03mg/kg) plus fentanyl (2μg/kg). The regions of interest were the anterior cingulate cortex, right basal ganglia, right frontal lobe, and right hippocampus. Twenty-five of these subjects underwent the second (1)H MRS session while awake. The measured (1)H MRS metabolites included N-acetyl-aspartate, creatine-containing compounds (PCr+Cr), choline-containing compounds, myo-inositol, and glutamate plus glutamine, which were quantified both as absolute values and metabolite/PCr+Cr ratios. The results were analyzed using independent group t tests and repeated measures analysis of variance (ANOVA, with alpha values set at 0.025 to minimize the risk of false-positive findings arising from multiple comparisons. No significant difference between subjects under midazolam plus fentanyl induced sedation and awake could be detected with unpaired analyses. Paired comparisons by ANOVA with repeated measures found that neither drug (midazolam plus fentanyl) nor the drug by time (interval between two scan times) interaction had a significant effect on the quantified metabolites. These findings encourage utilization of benzodiazepine-induced brief sedation during in vivo (1)H MRS experiments of the brain, and may help with elucidation of state-dependent neurochemical alterations during the course of bipolar and schizoaffective disorders. |
| | |
Authors:
|
Ayşegül Yildiz; Necati Gökmen; Semih Kücükgüclü; Ayşegül Yurt; David Olson; Elizabeth D Rouse; Constance Moore; Oğuz Dicle; Perry F Renshaw |
Related Documents
:
|
12918557 - Quantitative comparison between upper eyelid retraction induced voluntarily and by grav... 12467867 - 3-d echo planar (1)hmrs imaging in ms: metabolite comparison from supratentorial vs. ce... 17351427 - Proton magnetic resonance spectroscopic imaging in the border zone of gliomas: correlat... 9827617 - 1h magnetic resonance spectroscopy of the lentiform nucleus in primary focal hand dysto... 8771177 - Generalized chorea in an infant with semilobar holoprosencephaly. 3628767 - Failed temporomandibular joint prostheses: mr imaging. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-30 |
Journal Detail:
|
Title: Psychiatry research Volume: 184 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
|
Languages: eng Pagination: 162-70 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Psychiatry, Dokuz Eylül University, Mithatpasa Cad. No. 479, Narlidere, Izmir, Turkey. agul_yildiz@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
MH 58681/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Age-related cortical thinning in schizophrenia.
Next Document: Time-dependent adsorption behavior of ?-lactoglobulin on ZnSe crystal surface studied by 2D correlat...