Document Detail


In vivo proton magnetic resonance spectroscopy (MRS) study of post polio residual paralysis (PPRP) patients.
MedLine Citation:
PMID:  11973036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In-vivo proton MR spectroscopy carried out on post polio residual paralysis (PPRP) patients indicate that the presence or absence of intra-myocellular lipids (IMCL) is related to the severity of the paralysis. It is observed that mildly paralyzed patients are comparable (p > 0.05) with the control subjects in relation to the presence of IMCL, while moderate and severely paralysed patients are comparable (p > 0.05) in relation to the absence of IMCL. In addition, there is reduction or complete absence of creatine, carnitine and choline metabolites in severely paralyzed patients. The ability to detect noninvasively the subtle differences in in vivo, the lipid compartments of muscle may prove to be a valuable tool in understanding the pathogenesis of muscle diseases. This could open up the possibilities in designing effective rehabilitative exercise programs or development of new drug therapies.
Authors:
N R Jagannathan; Sanjay Wadhwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  20     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-04-25     Completed Date:  2002-05-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Affiliation:
Department of NMR, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. jagan1954@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Carnitine / metabolism
Child
Exercise / physiology
Feasibility Studies
Female
Humans
Lipid Metabolism*
Magnetic Resonance Spectroscopy / methods
Male
Muscle, Skeletal / pathology
Postpoliomyelitis Syndrome / classification,  diagnosis,  metabolism*
Severity of Illness Index
Chemical
Reg. No./Substance:
541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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