| In vivo photodynamic therapy and magnetic resonance imaging of cancer by TSPP-coated Fe3O4 nanoconjugates. | |
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MedLine Citation:
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PMID: 21361133 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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In this paper, we present the preparation and characterization of organic dye-coated magnetic particles and its application as magnetic resonance imaging (MRI) and photodynamic therapy (PDT) agent. We have coated the surface of Fe3O4 magnetic nanoparticles by meso-tetra(4-sulfonatophenyl) porphyrin dihydrochloride (TSPP), a photosensitive drug used in PDT, which is capable of generating singlet oxygen on the surface of paramagnetic Fe3O4 nanoparticles when irradiated at 400 nm. While the MRI was performed with in vivo mice experiment along with proper irradiation and therapeutic effect was followed by using in-situ MRI technology. The resulting conjugate is a single particle platform that can simultaneously be used as a PDT therapeutic and MRI contrasting agent. |
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Authors:
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Jun Ding; Jihong Zhao; Kailiang Cheng; Guifeng Liu; Dianhui Xiu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical nanotechnology Volume: 6 ISSN: 1550-7033 ISO Abbreviation: J Biomed Nanotechnol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-03-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230869 Medline TA: J Biomed Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 683-6 Citation Subset: IM |
Affiliation:
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3rd Clinical Hospital, Jilin University, Changchun 130033, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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