| In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia. | |
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MedLine Citation:
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PMID: 3992043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart. |
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Authors:
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C R Malloy; P M Matthews; M B Smith; G K Radda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Advances in myocardiology Volume: 6 ISSN: 0270-4056 ISO Abbreviation: Adv Myocardiol Publication Date: 1985 |
Date Detail:
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Created Date: 1985-06-14 Completed Date: 1985-06-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8000285 Medline TA: Adv Myocardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 461-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium Adenosine Triphosphate / metabolism Animals Coronary Circulation Coronary Disease / metabolism* Energy Metabolism* Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy / diagnostic use* Phosphates / metabolism Phosphocreatine / metabolism Phosphorus Isotopes / diagnostic use Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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HL-18708/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 0/Phosphorus Isotopes; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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