| In vivo oxidized low-density lipoprotein (ox-LDL) aopp and tas after kidney transplantation: a prospective, randomized one year study comparing cyclosporine A and tacrolimus based regiments. | |
| | |
MedLine Citation:
|
PMID: 22580856 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Aims. Restoration of renal function after kidney transplantation (KT) is expected to improve oxidative stress (OS). However, little is known about the influence of calcineurin inhibitors on oxidized low-density lipoproteins (ox-LDL) after KT. The aim of this study was to evaluate ox-LDLs and related markers of OS, advanced oxidation protein products (AOPP) and total antioxidant status (TAS) in patients after KT on either cyclosporin A (CyA) or tacrolimus (Tac) treatment. Methods. This was a prospective, randomized, single-center 12 month study evaluating time-dependent changes in biomarkers of OS before and after KT. Twenty nine patients (mean age 54.4 ± 11.1; 55% male and 45% female) were treated with CyA (Group A) and twenty four patients (mean age 52.9 ± 9.9; 75% male and 25% female) were treated with Tac (Group B). The ox-LDL, AOPP, TAS, lipid metabolism parameters, creatinine and glomerular filtration were assessed on day 1 before KT and on days 1 and 7, and in months 1, 3, 6 and 12 after KT. Results. Over the 12 months, the ox-LDL for group A changed from 69.2±32.9 to 65.1±17.1 U/L (P=0.665), while AOPP significantly decreased from 233.0±159.6 to 156.5±90.1 μmol/L (P=0.025) and TAS from 1.87±0.31 to 1.68±0.20 mmol/L (P=0.030). For group B the ox-LDL changed from 62.9±29.7 to ± 61.4±14.6 U/L (P=0.168) and TAS from 1.87±0.51 to 1.68±0.20 mmol/L (P=0.168), while AOPP significantly decreased from 180.5±90.0 to 123.9±37.7 μmol/L (P=0.019). Conclusion. AOPP is more sensitive than ox-LDL for assessing OS after KT. TAS values appear to be insufficiently sensitive for monitoring OS in patients after KT. |
| | |
Authors:
|
Josef Zadrazil; Pavel Horak; Pavel Strebl; Karel Krejci; Marketa Kajabova; Petr Schneiderka; Jana Zapletalova; Adela Galandakova; Jitka Vostalova; Helena Vaverkova |
Related Documents
:
|
18540926 - Femoral nerve block using ropivacaine 0.025%, 0.05% and 0.1%: effects on the rehabilita... 11465336 - Randomized trial of 10 ml and 20 ml of 2% intraurethral lidocaine gel and placebo in me... 11878736 - Evaluation of the greenbaum sub-tenon's block. 15587026 - Results of intravenous regional anaesthesia with distal forearm application. 22717726 - Magnesium sulphate: an adjuvant to tracheal intubation without muscle relaxation--a ran... 665406 - A clinical approach to the medical treatment of uveitis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia Volume: 156 ISSN: 1213-8118 ISO Abbreviation: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-05-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140142 Medline TA: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Country: Czech Republic |
Other Details:
|
Languages: eng Pagination: 14-20 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Czech Republic. josef.zadrazil@fnol.cz. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The in vitro antimicrobial activity of silicone oils used in ophthalmic surgery.
Next Document: Gender differences in total cholesterol levels in patients with acute heart failure and its importan...