Document Detail

In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat.
MedLine Citation:
PMID:  15270550     Owner:  NLM     Status:  MEDLINE    
Cyclic fatty acid monomers (CFAM), which occur from the intramolecular cyclisation of linoleic and linolenic acids, are subsequently present in some edible oils and are suspected to induce metabolic disorders. One may suggest that the presence of a ring would alter the ability of the organism to oxidise these molecules. In order to test this hypothesis, we assessed the oxidative metabolism of CFAM in rats. For this purpose, rats were force-fed from 1.5 to 2.6 MBq of [1-(14)C]-linoleic acid, [1-(14)C]-linolenic acid, [1-(14)C]-CFAM-18:2 or [1-(14)C]-CFAM-18:3, and 14CO2 production was monitored for 24 h. The animals were then sacrificed and the radioactivity was determined in different tissues. No significant differences in 14CO2 production were found 24 h after the administration of CFAM and their respective precursors. Our data clearly demonstrate that, at least for the first beta-oxidation cycle, CFAM are oxidised in a similar way as both essential fatty acids.
Florent Joffre; Alexandre Roy; Lionel Bretillon; Bruno Pasquis; Jean-Pierre Sergiel; Olivier Loreau; Jean-Michel Chardigny; Jean-Louis Sébédio
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, nutrition, development     Volume:  44     ISSN:  0926-5287     ISO Abbreviation:  Reprod. Nutr. Dev.     Publication Date:    2004 Mar-Apr
Date Detail:
Created Date:  2004-07-23     Completed Date:  2004-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913069     Medline TA:  Reprod Nutr Dev     Country:  France    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  IM    
Institut National de la Recherche Agronomique, Unité de Nutrition Lipidique, Dijon, France.
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MeSH Terms
Administration, Oral
Carbon Dioxide / analysis
Carbon Radioisotopes
Fatty Acids, Unsaturated / administration & dosage,  chemistry,  metabolism
Linoleic Acid / administration & dosage,  chemistry,  metabolism*
Organ Specificity
Rats, Wistar
Tissue Distribution
alpha-Linolenic Acid / administration & dosage,  chemistry,  metabolism*
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fatty Acids, Unsaturated; 124-38-9/Carbon Dioxide; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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