| In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser. | |
| | |
MedLine Citation:
|
PMID: 23212157 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
ABSTRACT. In vivo visualization of human skin aging is demonstrated using a Cr:Forsterite (Cr:F) laser-based, collagen-sensitive second harmonic generation (SHG) microscope. The deep penetration into human skin, as well as the specific sensitivity to collagen molecules, achieved by this microscope enables us to clearly visualize age-related structural changes of collagen fiber in the reticular dermis. Here we investigated intrinsic aging and/or photoaging in the male facial skin. Young subjects show dense distributions of thin collagen fibers, whereas elderly subjects show coarse distributions of thick collagen fibers. Furthermore, a comparison of SHG images between young and elderly subjects with and without a recent life history of excessive sun exposure show that a combination of photoaging with intrinsic aging significantly accelerates skin aging. We also perform image analysis based on two-dimensional Fourier transformation of the SHG images and extracted an aging parameter for human skin. The in vivo collagen-sensitive SHG microscope will be a powerful tool in fields such as cosmeceutical sciences and anti-aging dermatology. |
| | |
Authors:
|
Takeshi Yasui; Makoto Yonetsu; Ryosuke Tanaka; Yuji Tanaka; Shu-Ichiro Fukushima; Toyonobu Yamashita; Yuki Ogura; Tetsuji Hirao; Hiroyuki Murota; Tsutomu Araki |
Related Documents
:
|
18539947 - Age-related losses of retinal ganglion cells and axons. 23033137 - Influence of aging on the quality of the skin of white women: the role of collagen. 3681397 - Role of extraocular muscle proprioception in the development of depth perception in cats. 22080087 - The redox stress hypothesis of aging. 10391087 - Lung cancer in patients under 50 years old. 15378217 - Reference values for bone mineral density in 12- to 18-year-old girls categorized by we... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of biomedical optics Volume: 18 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2013 Mar |
Date Detail:
|
Created Date: 2012-12-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
|
Languages: eng Pagination: 31108 Citation Subset: IM |
Affiliation:
|
Osaka University, Graduate School of Engineering Science, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, JapanbUniversity of Tokushima, Institute of Technology and Science, 2-1 Minami-Josanjima, Tokushima 770-8506, JapancNara Medical University, Graduate School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the...
Next Document: Recurrent Pneumonia Caused by a Migrated Esophageal Foreign Body.