| In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes. | |
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MedLine Citation:
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PMID: 23151772 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 µM. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG. This implies that the SWNTs-ICG could be potentially utilized to identify SLNs in breast cancer patients and tracking vesicoureteral reflux in combination with PA imaging. |
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Authors:
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Jasung Koo; Mansik Jeon; Yunok Oh; Hyun Wook Kang; Jeehyun Kim; Chulhong Kim; Junghwan Oh |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 57 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: - |
Other Details:
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Languages: ENG Pagination: 7853-7862 Citation Subset: - |
Affiliation:
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Department of Mechatronics Engineering, Pukyong National University, Busan 608-737, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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