Document Detail

In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes.
MedLine Citation:
PMID:  23151772     Owner:  NLM     Status:  Publisher    
We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 µM. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG. This implies that the SWNTs-ICG could be potentially utilized to identify SLNs in breast cancer patients and tracking vesicoureteral reflux in combination with PA imaging.
Jasung Koo; Mansik Jeon; Yunok Oh; Hyun Wook Kang; Jeehyun Kim; Chulhong Kim; Junghwan Oh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Physics in medicine and biology     Volume:  57     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  7853-7862     Citation Subset:  -    
Department of Mechatronics Engineering, Pukyong National University, Busan 608-737, Korea.
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