Document Detail


In vivo non-invasive high resolution MR-based method for the determination of the elastic modulus of arterial vessels.
MedLine Citation:
PMID:  19163979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanical properties of arterial walls have long been recognized to play an essential role in the development and progression of cardiovascular disease (CVD). Early detection of variations in the elastic modulus of arteries would help in monitoring patients at high cardiovascular risk stratifying them according to risk. An in vivo, non-invasive, high resolution MR-phase-contrast based method for the estimation of the time-dependent elastic modulus of healthy arteries was developed, validated in vitro by means of a thin walled silicon rubber tube integrated into an existing MR-compatible flow simulator and used on healthy volunteers. A comparison of the elastic modulus of the silicon tube measured from the MRI-based technique with direct measurements confirmed the method's capability. The repeatability of the method was assessed. Viscoelastic and inertial effects characterizing the dynamic response of arteries in vivo emerged from the comparison of the pressure waveform and the area variation curve over a period. For all the volunteers who took part in the study the elastic modulus was found to be in the range 50-250 kPa, to increase during the rising part of the cycle, and to decrease with decreasing pressure during the downstroke of systole and subsequent diastole.
Authors:
Valentina Taviani; Michael P F Sutcliffe; Pauline Wong; Zhi-Yong Li; Victoria Young; Martin J Graves; Jonathan H Gillard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2008     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2008  
Date Detail:
Created Date:  2009-02-16     Completed Date:  2009-05-12     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5569-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Algorithms*
Arteries / anatomy & histology*,  physiology*
Elastic Modulus / physiology
Elasticity Imaging Techniques / methods*
Humans
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Reproducibility of Results
Sensitivity and Specificity
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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