Document Detail


In vivo nicotine exposure in the zebra finch: a promising innovative animal model to use in neurodegenerative disorders related research.
MedLine Citation:
PMID:  20471408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nicotine improves cognitive enhancement and there are indications that neurodegenerative (age-related) cognitive disorders could be treated with nicotine-based drugs. The zebra finch is a well-recognized model to study cognitive functioning; hence this model could be used to study the effects of nicotine in neurodegenerative cognitive disorders. However, nicotine's in vivo physiological and behavioral effects have never been studied in the zebra finch. Here we present the first in vivo nicotine study in zebra finches. We evaluated the dose-response effects of nicotine on locomotor activity, song production, food intake and body weight. A liquid chromatography tandem mass spectrometry method was developed and validated for quantification of nicotine and cotinine in feces. The subcutaneous nicotine drug regiment (0.054-0.54mg/kg) induced physiologically significant values of nicotine and cotinine. The mid (0.18mg/kg) and high (0.54mg/kg) dose of nicotine promoted the development and expression of a sensitized response of song production and locomotor activity. Food intake and body weight were not affected following nicotine exposure. In conclusion, the zebra finch can be used as an innovative animal model not only in nicotine-related research studying cognitive functioning, but also in studies examining nicotine dependence and addictive mechanisms.
Authors:
S L T Cappendijk; D F Pirvan; G L Miller; M I Rodriguez; P Chalise; M S Halquist; J R James
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-13
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  96     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
College of Medicine, Dept. of Biomedical Sciences, Florida State University, Tallahassee FL 32306-4300, USA. susanne.cappendijk@med.fsu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Chromatography, Liquid / methods
Cotinine / analysis
Disease Models, Animal*
Dose-Response Relationship, Drug
Eating / drug effects
Feces / chemistry
Finches / metabolism*
Male
Motor Activity / drug effects
Neurodegenerative Diseases / drug therapy*
Nicotine / administration & dosage,  analysis,  pharmacology*
Songbirds / metabolism
Tandem Mass Spectrometry / methods
Vocalization, Animal / drug effects
Chemical
Reg. No./Substance:
486-56-6/Cotinine; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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