| In vivo neuropathology of cortical changes in elderly persons with schizophrenia. | |
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MedLine Citation:
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PMID: 19409532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Elderly schizophrenia patients frequently develop cognitive impairment of unclear etiology. Magnetic resonance imaging (MRI) studies revealed brain structural abnormalities, but the pattern of cortical gray matter (GM) volume and its relationship with cognitive and behavioral symptoms are unknown. METHODS: Magnetic resonance scans were taken from elderly schizophrenia patients (n = 20, age 67 +/- 6 SD, Mini-Mental State Examination [MMSE] 23 +/- 4), Alzheimer's disease (AD) patients (n = 20, age 73 +/- 9, MMSE 22 +/- 4), and healthy elders (n = 20, age 73 +/- 8, MMSE 29 +/- 1). Patients were assessed with a comprehensive neuropsychological and behavioral battery. Cortical pattern matching and a region-of-interest analysis, based on Brodmann areas (BAs), were used to map three-dimensional (3-D) profiles of differences in patterns of gray matter volume among groups. RESULTS: Schizophrenia patients had 10% and 11% lower total left and right GM volume than healthy elders (p < .001) and 7% and 5% more than AD patients (p = .06 and ns). Regions that had both significantly less gray matter than control subjects and gray matter volume as low as AD mapped to the cingulate gyrus and orbitofrontal cortex (BA 30, 23, 24, 32, 25, 11). The strongest correlate of gray matter volume in elderly schizophrenia patients, although nonsignificant, was the positive symptom subscale of the Positive and Negative Syndrome Scale, mapping to the right anterior cingulate area (r = .42, p = .06). CONCLUSIONS: The orbitofrontal/cingulate region had low gray matter volume in elderly schizophrenia patients. Neither cognitive impairment nor psychiatric symptoms were significantly associated with structural differences, even if positive symptoms tended to be associated with increased gray matter volume in this area. |
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Authors:
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Giovanni B Frisoni; Annapaola Prestia; Andrea Adorni; Paul E Rasser; Maria Cotelli; Andrea Soricelli; Matteo Bonetti; Cristina Geroldi; Panteleimon Giannakopoulos; Paul M Thompson |
Publication Detail:
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Type: Journal Article Date: 2009-05-01 |
Journal Detail:
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Title: Biological psychiatry Volume: 66 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-28 Completed Date: 2009-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 578-85 Citation Subset: IM |
Affiliation:
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LENITEM-Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, the National Centre for Research and Care of Alzheimer's and Mental Diseases, Brescia, Italy. gfrisoni@fatebenefratelli.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / pathology* Alzheimer Disease / pathology Brain Mapping* Cerebral Cortex / pathology* Female Humans Imaging, Three-Dimensional / methods Magnetic Resonance Imaging / methods Male Middle Aged Neuropsychological Tests Psychiatric Status Rating Scales Schizophrenia / pathology* Statistics as Topic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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