| In vivo neurochemistry of primary focal hand dystonia: a magnetic resonance spectroscopic neurometabolite profiling study at 3T. | |
| | |
MedLine Citation:
|
PMID: 20979122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The neurochemical basis of dystonia is unknown. The purpose of this study was to assess the differences of the inhibitory neurotransmitter, gamma amino butyric acid (GABA), in the sensorimotor cortex and the basal ganglia using magnetic resonance spectroscopy with optimized GABA sensitivity. Twenty-two patients with focal hand dystonia and 22 healthy controls were studied. No significant differences in GABA were observed between the groups in either the sensorimotor cortex or in the basal ganglia. |
| | |
Authors:
|
Priyantha Herath; Cecile Gallea; Jan Willem van der Veen; Silvina G Horovitz; Mark Hallett |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Movement disorders : official journal of the Movement Disorder Society Volume: 25 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-17 Completed Date: 2011-04-08 Revised Date: 2011-12-19 |
Medline Journal Info:
|
Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
|
Languages: eng Pagination: 2800-8 Citation Subset: IM |
Copyright Information:
|
© Movement Disorder Society. |
Affiliation:
|
Medical Neurology Branch, Human Motor Control Section, NINDS/NIH, Bethesda, Maryland, USA. herapx@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Basal Ganglia / metabolism*, pathology Botulinum Toxins, Type A / therapeutic use Cerebral Cortex / metabolism*, pathology Dystonic Disorders / metabolism*, pathology, therapy Humans Magnetic Resonance Spectroscopy Middle Aged Neuromuscular Agents / therapeutic use gamma-Aminobutyric Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
Z01 NS002667-24/NS/NINDS NIH HHS; Z01 NS003031-02/NS/NINDS NIH HHS; ZIA NS002667-25/NS/NINDS NIH HHS; ZIA NS003031-03/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Neuromuscular Agents; 56-12-2/gamma-Aminobutyric Acid; EC 3.4.24.69/Botulinum Toxins, Type A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Severe reversible hyperkinesia due to polycythemia (Rubra) vera.
Next Document: Update of cancer and non-cancer mortality in the Missouri poultry cohort.