Document Detail


In vivo muscle architecture and size of the rectus femoris and vastus lateralis in children and adolescents with cerebral palsy.
MedLine Citation:
PMID:  19459913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Our aim was to investigate muscle architecture and size of the rectus femoris (RF) and vastus lateralis (VL) in children and adolescents with cerebral palsy (CP) compared with age-matched typically developing participants.
METHOD: Muscle architecture and size were measured with ultrasound imaging in 18 participants with spastic CP (9 females, 9 males; age range 7.5-19 y; mean age 12 y [SD 3 y 2 mo]) within Gross Motor Function Classification System levels I (n=4), II (n=2), III (n=9), and IV (n=3) and 12 typically developing participants (10 females, 2 males; age range 7-20 y; mean age 12 y 4 mo [SD 3 y 11 mo]). Exclusion criteria were orthopedic surgery or neurosurgery within 6 months before testing or botulinum toxin injections to the quadriceps within 3 months before testing.
RESULTS: RF cross-sectional area was significantly lower (48%), RF and VL muscle thickness 30% lower, RF fascicle length 27% lower, and VL fascicle angle 3 degrees less in participants with CP compared to the typically developing participants (p<0.05). Intraclass correlation coefficients were >or=0.93 (CP) and >or= 0.88 (typical development), indicating excellent reliability.
INTERPRETATION: These results provide the first evidence of altered muscle architecture and size of the RF and VL in CP, similar to patterns observed with disuse and aging. These alterations may play a significant role in the decreased capacity for force generation as well as decreased shortening velocity and range of motion over which the quadriceps can act.
Authors:
Noelle G Moreau; Sharlene A Teefey; Diane L Damiano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-04-21
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  51     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2009-09-29     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  800-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Case-Control Studies
Cerebral Palsy / pathology*,  ultrasonography
Child
Female
Humans
Male
Quadriceps Muscle / pathology*,  ultrasonography
Reproducibility of Results
Ultrasonography / methods
Young Adult
Grant Support
ID/Acronym/Agency:
T32 HD007434/HD/NICHD NIH HHS; T32 HD007434-16/HD/NICHD NIH HHS; T32HD007434-16/HD/NICHD NIH HHS
Comments/Corrections
Comment In:
Dev Med Child Neurol. 2009 Oct;51(10):768-9   [PMID:  19549205 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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