| In vivo microvascular actions of Artemisia vulgaris L. in a model of ischemia-reperfusion injury in the rat intestinal mesentery. | |
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MedLine Citation:
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PMID: 11321436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Water extract fractions of leaves from Artemisia vulgaris L. (commonly known as mugwort) were tested for their effects on tissue damage brought about by ischemia-reperfusion injury in the rat mesentery. Male Sprague-Dawley rats, 200-300 grams in weight were divided into two groups, control and treatment (AV) group. All rats were anesthetized with ketamine HCl administered intramuscularly, tracheotomized and cannulated in one carotid artery and one jugular vein. After a midline abdominal incision, the mesenteric area was exteriorized and observed using videomicroscopy. After baseline observations of systemic blood pressure, heart rate, venular diameters and leukocyte adhesion along venules, the mesenteric artery and vein were occluded for 10 minutes. Prior to occlusion, A. vulgaris-treated animals were given a bolus injection of a 1% w/v solution of extracts, while the control group received saline. Monastral Blue dye was also administered before the occlusion at a dose of 30 mg/kg via the jugular vein in order to assess transendothelial leakage. Hemodynamic and cellular parameters were measured immediately after the release of occlusion and at 10 minute intervals thereafter. Results show that the extracts had no significant effects on mean blood pressures and heart rates, but appeared to significantly reduce leukocyte adherence and transendothelial leakage while improving flow in the ischemia-reperfused organ. The extract fractions contain yomogin, which has been previously shown to inhibit iNOS activity, and may therefore explain the anti-inflammatory property of the plant. |
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Authors:
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X T Tigno; E Gumila |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 23 ISSN: 1386-0291 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2000 |
Date Detail:
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Created Date: 2001-04-25 Completed Date: 2001-09-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Affiliation:
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Department of Physiology, College of Medicine, University of the Philippines Manila, Ermita. xtigno@i-next.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology, therapeutic use Artemisia / chemistry* Blood Pressure / drug effects Capillary Leak Syndrome / etiology, prevention & control* Cell Adhesion / drug effects Drug Evaluation, Preclinical Enzyme Inhibitors / pharmacology, therapeutic use Heart Rate / drug effects Hemodynamics / drug effects* Hexanes Intestines / blood supply* Ischemia / drug therapy*, etiology, physiopathology Lactones / isolation & purification, pharmacology, therapeutic use Leukocytes / drug effects* Male Mesenteric Vascular Occlusion / complications* Microscopy, Video Nitric Oxide Synthase / antagonists & inhibitors Nitric Oxide Synthase Type II Plant Extracts / isolation & purification, pharmacology, therapeutic use Plants, Medicinal* Rats Rats, Sprague-Dawley Reperfusion Injury / etiology, physiopathology, prevention & control* Sesquiterpenes / isolation & purification, pharmacology, therapeutic use Sesquiterpenes, Eudesmane* Splanchnic Circulation / drug effects* Water |
| Chemical | |
Reg. No./Substance:
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0/1,2,3,4-diepoxy-11(13)-eudesmen-12,8-olide; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Enzyme Inhibitors; 0/Hexanes; 0/Lactones; 0/Plant Extracts; 0/Sesquiterpenes; 0/Sesquiterpenes, Eudesmane; 0/yomogin; 110-54-3/n-hexane; 7732-18-5/Water; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nos2 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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