| In vivo microscopy in a porcine model of acute lung injury. | |
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MedLine Citation:
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PMID: 20638978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regional inhomogeneity and alveolar mechanics in a porcine model of acute lung injury (ALI) was evaluated using confocal laser scanning microscopy (CLSM). CLSM was performed through thoracic windows of the upper and lower lobes. Image quantification was conducted by use of a volume air index (VAI). Twelve anesthetized, mechanically ventilated pigs were randomized to non-injury (control group, n = 6) or ALI induced by surfactant depletion (ALI group, n = 6). CLSM was performed at baseline, after 1 h at 5 mbar and after 2 h at 15 mbar positive end-expiratory pressure (PEEP). Haemodynamics, respiratory mechanics and calculation of pulmonary ventilation-perfusion distribution by MIGET were determined. At baseline, VAI was not different. In the upper lobes, VAI significantly decreased in ALI compared to control group, with no changes after PEEP application. In the lower lobes, VAI significantly decreased in ALI compared to control group. Incremental PEEP significantly increased VAI in ALI, but not in control group. Haemodynamics were significantly compromised in the ALI group. A significant deterioration in oxygenation and ventilation-perfusion distribution could be seen being restored after PEEP adjustment. The VAI may help to assess regional inhomogeneity of the acutely injured lung. |
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Authors:
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Johannes Bickenbach; Michael Czaplik; Rolf Dembinski; Paolo Pelosi; Wolfgang Schroeder; Gernot Marx; Rolf Rossaint |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 172 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 192-200 Citation Subset: IM |
Affiliation:
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Department of Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. jbickenbach@ukaachen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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pathology* Animals Body Temperature Data Interpretation, Statistical Female Hemodynamics / physiology Image Processing, Computer-Assisted Microscopy, Confocal Peak Expiratory Flow Rate / physiology Pulmonary Alveoli / physiology Pulmonary Artery / physiology Pulmonary Circulation / physiology Respiratory Mechanics / physiology Swine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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