Document Detail

In vivo microdialysis in awake, freely moving rats demonstrates HIV-1 Tat-induced alterations in dopamine transmission.
MedLine Citation:
PMID:  19086089     Owner:  NLM     Status:  MEDLINE    
Individuals infected with human immunodeficiency virus (HIV) may develop neuropsychological impairment, and a modest percentage may progress to HIV-associated dementia (HAD). Research using human and nonhuman, in vitro and in vivo models, demonstrates that subcortical dopamine (DA) systems may be particularly vulnerable to HIV-induced neurodegeneration. The goal of the current investigation is to provide an understanding of the extent to which the HIV-1 protein Tat induces alterations in striatal DA transmission using in vivo brain microdialysis in awake, freely moving rats. The current study was designed to investigate Tat-induced neuronal dysfunction between 24-h and 48-h post-Tat administration, and demonstrates a reduction in evoked DA for the Tat-treated group relative to vehicle-treated group at 24 and 48 h. The Tat-induced reduction of DA overflow by 24 h suggests dysfunction of nerve terminals, and a compromised DA system in Tat-treated animals. Furthermore, the current study provides direct support for HIV-associated decline of DA function at a systemic level, helping to characterize the functional outcome of the relatively large amount of research on the molecular and behavioral levels of HIV-induced neurotoxicity. This initial study may provide additional characteristics of Tat-induced neuronal dysfunction to inform research on therapeutic intervention, and it provides a springboard for future in vivo research currently needed in the field.
Mark J Ferris; Danielle Frederick-Duus; Jim Fadel; Charles F Mactutus; Rosemarie M Booze
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  63     ISSN:  1098-2396     ISO Abbreviation:  Synapse     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-04-08     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
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MeSH Terms
Chromatography, High Pressure Liquid / methods
Corpus Striatum / drug effects*
Dopamine / metabolism*
Microdialysis / methods
Rats, Sprague-Dawley
Synaptic Transmission / drug effects,  physiology*
Time Factors
tat Gene Products, Human Immunodeficiency Virus / metabolism,  pharmacology*
Grant Support
DA 013137/DA/NIDA NIH HHS; DA 014401/DA/NIDA NIH HHS; HD 043680./HD/NICHD NIH HHS; K02 DA014401/DA/NIDA NIH HHS; R01 DA013137/DA/NIDA NIH HHS; R01 DA013137-10/DA/NIDA NIH HHS; R01 DA013137-11/DA/NIDA NIH HHS; R01 HD043680/HD/NICHD NIH HHS
Reg. No./Substance:
0/tat Gene Products, Human Immunodeficiency Virus; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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