Document Detail


In vivo metabolism of retrorsine and retrorsine-N-oxide.
MedLine Citation:
PMID:  8452478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vivo metabolism and excretion of the urinary metabolites from the pyrrolizidine alkaloids (PAs), retrorsine (RET) and retrorsine-N-oxide (RET-NO) have been studied in rats. Isatinecic acid (INA), pyrrolic metabolites, N-oxides and retronecine accounted for 31.0, 10.3, 10.8 and 0.39% of the administered RET. Predosing rats with triorthocresyl phosphate (TOCP), had no effect on the excretion of pyrrolic metabolites and INA. Phenobarbital (PB) increased the excretion of both pyrrolic metabolites and INA with a corresponding decrease in the excretion of RET and N-oxides; the retronecine levels remained unaltered. When RET-NO was administered i.p., the urinary levels of pyrrolic metabolites, INA and RET were decreased relative to those treated with RET. The p.o. administration of RET-NO produced significantly higher levels of pyrrolic metabolites, INA and RET. These results suggest that esterase hydrolysis plays a minor role in the formation of INA and that a common metabolic pathway may exist between pyrrolic metabolites and INA formation.
Authors:
P S Chu; M W Lamé; H J Segall
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of toxicology     Volume:  67     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-04-15     Completed Date:  1993-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Affiliation:
Department of Veterinary Pharmacology and Toxicology, University of California, Davis 95616.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Gas
Chromatography, High Pressure Liquid
Dicarboxylic Acids / metabolism
Male
Phenobarbital / pharmacology
Plants, Toxic
Pyrroles / chemistry,  urine
Pyrrolizidine Alkaloids / metabolism*
Rats
Rats, Sprague-Dawley
Senecio / chemistry
Tritolyl Phosphates / pharmacology
Grant Support
ID/Acronym/Agency:
ES-03343/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Dicarboxylic Acids; 0/Pyrroles; 0/Pyrrolizidine Alkaloids; 0/Tritolyl Phosphates; 15503-86-3/isatidine; 34081-90-8/isatinecic acid; 480-54-6/retrorsine; 50-06-6/Phenobarbital; 78-30-8/tri-o-cresyl phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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