| In vivo metabolism and kinetics of ethylene glycol monobutyl ether and its metabolites, 2-butoxyacetaldehyde and 2-butoxyacetic acid, as measured in blood, liver and forestomach of mice. | |
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MedLine Citation:
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PMID: 15672755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Ethylene glycol monobutyl ether (EGBE) causes forestomach hyperplasia and neoplasia in mice when administered chronically by inhalation. 2. The study was initiated to test the physiologically based pharmacokinetic (PBPK) model prediction that 2-butoxyacetaldehyde (BAL), a transient, labile intermediate in the oxidation of EGBE to butoxyacetic acid (BAA), is unlikely to achieve concentrations sufficient to cause DNA damage in target tissues. 3. Male and female B6C3F1 mice were administered a high oral dose of EGBE (600mgkg(-1)), and tissues were collected at 5, 15, 45 and 90min following the dose. The tissues were processed for determination of EGBE, BAL and BAA by gas chromatography-mass spectrometry. 4. BAL was detected at low concentrations in all tissues sampled and at all time points following EGBE administration (about 0.3-33 microM). BAL concentrations were highest in the initial samples (5 min) in all tissues and declined from that point. 5. BAL concentrations in liver and forestomach tissues corresponded to the peak concentrations predicted by an already published PBPK model, and are higher than BAL concentrations that could be achieved by inhalation exposure to EGBE. 6. Mouse inhalation exposure to EGBE is therefore unlikely to generate BAL concentrations in tissues sufficient to initiate a carcinogenic response. |
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Authors:
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P J Deisinger; R J Boatman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 34 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2005-01-27 Completed Date: 2005-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: England |
Other Details:
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Languages: eng Pagination: 675-85 Citation Subset: IM |
Affiliation:
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Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY 14652-6272, USA. peter.deisinger@kodak.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaldehyde
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analogs & derivatives*,
blood,
metabolism* Administration, Oral Animals Dose-Response Relationship, Drug Ethylene Glycols / administration & dosage, metabolism, pharmacokinetics* Female Glycolates / blood, metabolism* Kinetics Liver / drug effects, metabolism* Male Mice Mice, Inbred Strains Stomach / drug effects, metabolism* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Ethylene Glycols; 0/Glycolates; 111-76-2/n-butoxyethanol; 2516-93-0/n-butoxyacetic acid; 29043-89-8/n-butoxyacetaldehyde; 75-07-0/Acetaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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