| In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat. | |
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MedLine Citation:
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PMID: 3472526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N-demethylation, O-demethylation, and N-oxidation. The analysis of metabolic profiles in various tissues led to the identification of the N-oxides as major metabolites. The successful inhibition and redirection of metabolism away from the indole acids towards the parent compounds and their structurally unique metabolites were demonstrated in animals pretreated with iproniazid. |
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Authors:
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B R Sitaram; L Lockett; R Talomsin; G L Blackman; W R McLeod |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical pharmacology Volume: 36 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-06-25 Completed Date: 1987-06-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1509-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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metabolism* Animals Brain / metabolism* Iproniazid / pharmacology Kidney / metabolism* Kinetics Liver / metabolism* Male Methoxydimethyltryptamines / metabolism* N,N-Dimethyltryptamine / metabolism* Rats Rats, Inbred Strains Serotonin / analogs & derivatives* Tryptamines / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Methoxydimethyltryptamines; 0/Tryptamines; 50-67-9/Serotonin; 54-92-2/Iproniazid; 61-50-7/N,N-Dimethyltryptamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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