Document Detail


In vivo measurement of plaque burden in a mouse model of Alzheimer's disease.
MedLine Citation:
PMID:  17036339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To demonstrate an MRI method for directly visualizing amyloid-beta (Abeta) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T1rho relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain.
MATERIALS AND METHODS: We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T1rho via quantitative relaxometric maps.
RESULTS: A significant decrease in T1rho was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T1rho and the age of the animals.
CONCLUSION: T1rho relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice.
Authors:
Arijitt Borthakur; Tamar Gur; Andrew J Wheaton; Matthew Corbo; John Q Trojanowski; Virginia M-Y Lee; Ravinder Reddy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  24     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-01-30     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1011-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 Wiley-Liss, Inc.
Affiliation:
Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA. ari@mail.mmrrcc.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / pathology*
Animals
Disease Models, Animal*
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Mice
Mice, Transgenic
Plaque, Amyloid / pathology*
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
P41 RR002305/RR/NCRR NIH HHS; P41 RR002305-236875/RR/NCRR NIH HHS; P41 RR002305-246021/RR/NCRR NIH HHS; P41 RR002305-255549/RR/NCRR NIH HHS; RR02305/RR/NCRR NIH HHS
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