Document Detail

In vivo measurement of local aortic pulse-wave velocity in mice with MR microscopy at 17.6 Tesla.
MedLine Citation:
PMID:  19353665     Owner:  NLM     Status:  MEDLINE    
Transgenic mouse models of human diseases have gained increasing importance in the pathophysiology of cardiovascular diseases (CVD). As an indirect measure of vascular stiffness, aortic pulse-wave velocity (PWV) is an important predictor of cardiovascular risk. This study presents an MRI approach that uses a flow area method to estimate local aortic pulse-wave velocity at different sites in the murine aorta. By simultaneously measuring the cross-sectional area and the through-plane velocity with a phase-contrast CINE method, it was possible to measure average values for the PWV in the ascending and descending aorta within the range of 2.4-4.3 m/s for C57BL/6J mice (ages 2 and 8 months) and apoE-knockout mice (age 8 months). Statistically significant differences of the mean values of the PWV of both groups could be determined. By repeating CINE measurements with a time delay of 1 ms between two subsequent data sets, an effective temporal resolution of 1000 frames/s (fps) could be achieved.
Volker Herold; Marco Parczyk; Philipp Mörchel; Christian H Ziener; Gert Klug; Wolfgang R Bauer; Eberhard Rommel; Peter M Jakob
Related Documents :
15912585 - Beam forming of ultra-wideband pulses by a complex-valued spatio-temporal multilayer ne...
17411205 - Analysis of a modular generator for high-voltage, high-frequency pulsed applications, u...
19471345 - 24.3-ps gaussian pulse transmission over ultrahigh-pmd fiber.
22049115 - Quasi-transverse ultrasound absorption due to point defects and anharmonic scattering p...
18531385 - Aeroacoustic production of speech sounds.
21997095 - Design studies for asic implementations of 28 gs/s optical qpsk- and 16-qam-ofdm transc...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  61     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1293-9     Citation Subset:  IM    
Julius-Maximilians-Universität Würzburg, Lehrstuhl für Experimentelle Physik 5, Würzburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta / anatomy & histology,  physiology*
Apolipoproteins E / genetics*
Blood Flow Velocity / physiology*
Magnetic Resonance Angiography / methods*,  veterinary
Magnetic Resonance Imaging, Cine / methods*
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Microscopy / methods*,  veterinary
Pulsatile Flow / physiology*
Reg. No./Substance:
0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reproducibility of cerebral phenylalanine levels in patients with phenylketonuria determined by 1H-M...
Next Document:  B1(+) interferometry for the calibration of RF transmitter arrays.