Document Detail


In vivo measurement of local aortic pulse-wave velocity in mice with MR microscopy at 17.6 Tesla.
MedLine Citation:
PMID:  19353665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transgenic mouse models of human diseases have gained increasing importance in the pathophysiology of cardiovascular diseases (CVD). As an indirect measure of vascular stiffness, aortic pulse-wave velocity (PWV) is an important predictor of cardiovascular risk. This study presents an MRI approach that uses a flow area method to estimate local aortic pulse-wave velocity at different sites in the murine aorta. By simultaneously measuring the cross-sectional area and the through-plane velocity with a phase-contrast CINE method, it was possible to measure average values for the PWV in the ascending and descending aorta within the range of 2.4-4.3 m/s for C57BL/6J mice (ages 2 and 8 months) and apoE-knockout mice (age 8 months). Statistically significant differences of the mean values of the PWV of both groups could be determined. By repeating CINE measurements with a time delay of 1 ms between two subsequent data sets, an effective temporal resolution of 1000 frames/s (fps) could be achieved.
Authors:
Volker Herold; Marco Parczyk; Philipp Mörchel; Christian H Ziener; Gert Klug; Wolfgang R Bauer; Eberhard Rommel; Peter M Jakob
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  61     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1293-9     Citation Subset:  IM    
Affiliation:
Julius-Maximilians-Universität Würzburg, Lehrstuhl für Experimentelle Physik 5, Würzburg, Germany. vrherold@physik.uni-wuerzburg.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / anatomy & histology,  physiology*
Apolipoproteins E / genetics*
Blood Flow Velocity / physiology*
Magnetic Resonance Angiography / methods*,  veterinary
Magnetic Resonance Imaging, Cine / methods*
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Microscopy / methods*,  veterinary
Pulsatile Flow / physiology*
Chemical
Reg. No./Substance:
0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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