Document Detail


In vivo measurement of dopamine and its metabolites by intracerebral dialysis: changes after d-amphetamine.
MedLine Citation:
PMID:  6196446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By using a new technique, intracerebral dialysis, in combination with high performance liquid chromatography and electrochemical detection, it was possible to recover and measure endogenous extracellular dopamine, together with its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) from the striatum and nucleus accumbens of anaesthetized or freely moving rats. In addition, measurements of extracellular 5-hydroxyindoleacetic acid, ascorbic acid, and uric acid were made. Basal extracellular concentrations of dopamine and DOPAC in the striatum were estimated to be 5 X 10(-8) M and 5 X 10(-6) M, respectively. d-Amphetamine (2 mg/kg s.c.) increased dopamine levels in the striatum perfusates by 14-fold, whereas levels of DOPAC and HVA decreased by 77% and 66%, respectively.
Authors:
T Zetterström; T Sharp; C A Marsden; U Ungerstedt
Related Documents :
10586966 - The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cer...
6198176 - Determination of alphamethyldopa, dihydroxyphenylacetic acid and 5-hydroxyindolacetic a...
25142786 - A new meroterpenoid tatenoic acid from the fungus neosartorya tatenoi kku-2nk23.
18398226 - Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities i...
19470386 - Rosmarinic acid suppresses retinal neovascularization via cell cycle arrest with increa...
25420516 - Essential oil of psidium cattleianum leaves: antioxidant and antifungal activity.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  41     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1769-73     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / analysis
Animals
Ascorbic Acid / analysis
Brain / drug effects
Brain Chemistry*
Dextroamphetamine / pharmacology*
Dialysis / methods
Dopamine / analysis*
Homovanillic Acid / analysis
Hydroxyindoleacetic Acid / analysis
Male
Rats
Rats, Inbred Strains
Uric Acid / analysis
Chemical
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-81-7/Ascorbic Acid; 51-64-9/Dextroamphetamine; 54-16-0/Hydroxyindoleacetic Acid; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chemical analysis of organotypic cultures of mouse spinal cord in normal, demyelinative, and nondemy...
Next Document:  Spontaneous and experimental neuritis and the distribution of the myelin protein P2 in the nervous s...