| In vivo magnetic resonance spectroscopy measurement of gray-matter and white-matter gamma-aminobutyric acid concentration in sensorimotor cortex using a motion-controlled MEGA point-resolved spectroscopy sequence. | |
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MedLine Citation:
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PMID: 21232891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the brain. Understanding the GABA concentration, in vivo, is important to understand normal brain function. Using MEGA point-resolved spectroscopy sequence with interleaved water scans to detect subject motion, GABA level of sensorimotor cortex was measured using a voxel identified from a functional magnetic resonance imaging scan. The GABA level in a 20×20×20-mm(3) voxel consisting of 37%±7% gray matter, 52%±12% white matter and 11%±8% cerebrospinal fluid in the sensorimotor region was measured to be 1.43±0.48 mM. In addition, using linear regression analysis, GABA concentrations within gray and white matter were calculated to be 2.87±0.61 and 0.33±0.11 mM, respectively. |
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Authors:
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Pallab K Bhattacharyya; Micheal D Phillips; Lael A Stone; Mark J Lowe |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-12 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 29 ISSN: 1873-5894 ISO Abbreviation: Magn Reson Imaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-14 Completed Date: 2011-08-09 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: Netherlands |
Other Details:
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Languages: eng Pagination: 374-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Imaging Institute, The Cleveland Clinic, Cleveland, OH 44195, USA. bhattap@ccf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Magnetic Resonance Imaging / methods* Magnetic Resonance Spectroscopy / methods* Male Motion Motor Cortex / metabolism*, pathology Nerve Fibers, Myelinated / metabolism*, pathology Neurons / metabolism*, pathology Somatosensory Cortex / metabolism*, pathology Tissue Distribution gamma-Aminobutyric Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R21 EB005302-01A1/EB/NIBIB NIH HHS; R21 EB005302-02/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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