| In vivo magnetic resonance imaging of injected mesenchymal stem cells in rat myocardial infarction; simultaneous cell tracking and left ventricular function measurement. | |
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MedLine Citation:
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PMID: 19132547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether magnetic resonance imaging (MRI) can enable magnetically labeled mesenchymal stem cell (MSC) tracking and simultaneous in vivo functional data acquisition in rat models of myocardial infarction. Superparamagnetic iron oxide-laden human MSCs were injected into rat myocardium infarcted by cryoinjury 3 weeks after myocardial infarction. The control group received cell-free media injection. Before injection and for 3 months after, in vivo serial MRI was performed. Electrocardiography-gated gradient echo sequence MRI and cine MRI were performed for in vivo cell tracking and assessing cardiac function using left ventricular ejection fraction (LVEF), respectively. MRI revealed a persistent signal-void representing iron-laden MSCs until ten post-injection weeks. Serial follow-up MRI revealed that LVEF was significantly higher in the MSC injection group than in the control group. We conclude that MRI enables in vivo tracking of injected cells and evaluation of the long-term therapeutic potential of MSCs for myocardial infarction. |
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Authors:
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Young Jin Kim; Yong-Min Huh; Kyu Ok Choe; Byoung Wook Choi; Eun Jeong Choi; Yangsoo Jang; Jae Myun Lee; Jin-Suck Suh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-09 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: 25 Suppl 1 ISSN: 1875-8312 ISO Abbreviation: Int J Cardiovasc Imaging Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-24 Completed Date: 2009-07-09 Revised Date: 2013-04-11 |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 99-109 Citation Subset: IM |
Affiliation:
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Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, 120-752 Seoul, South Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement* Cells, Cultured Contrast Media / diagnostic use Dextrans Disease Models, Animal Electrocardiography Ferumoxytol Humans Iron / diagnostic use Magnetic Resonance Imaging, Cine* Magnetite Nanoparticles Male Mesenchymal Stem Cell Transplantation* Myocardial Infarction / pathology, physiopathology, surgery* Myocardium / pathology* Oxides / diagnostic use Rats Rats, Sprague-Dawley Stroke Volume Time Factors Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Magnetite Nanoparticles; 0/Oxides; 1317-61-9/Ferumoxytol; 7439-89-6/Iron; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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