Document Detail

In vivo investigation of white matter pathology in schizophrenia with magnetisation transfer imaging.
MedLine Citation:
PMID:  10601405     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study is the first to use magnetisation transfer imaging (MTI), a technique sensitive to myelin and axonal abnormalities, to investigate the white matter in vivo in patients with schizophrenia.
METHODS: MTI was performed in 25 schizophrenic patients and 30 healthy controls. A region of interest (ROI) approach was used to obtain magnetisation transfer ratios (MTRs) in several regions of cerebral white matter.
RESULTS: MTR values were significantly reduced in the right and left temporal regions in schizophrenic patients compared with controls (p<0.001). Clinical variables such as age, duration of symptoms, schizophrenic symptomatology, and soft neurological signs did not predict this reduction in MTR. There were no MTR abnormalities in the other regions sampled. However, the correlation between the left and right frontal MTR values was marginally significantly different in schizophrenic patients compared with controls suggesting that subtle differences in interhemispheric connections may be present.
CONCLUSIONS: Subtle white matter pathology, most likely related to myelin and axonal abnormalities, can be detected in the temporal lobes in schizophrenic patients. MTI may be a useful tool in investigating the white matter in schizophrenia.
J Foong; M Maier; G J Barker; S Brocklehurst; D H Miller; M A Ron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  68     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Institute of Neurology, London, UK.
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MeSH Terms
Brain / pathology*
Magnetic Resonance Imaging / methods*
Middle Aged
Psychiatric Status Rating Scales
Schizophrenia / pathology*
Schizophrenic Psychology
Grant Support
491//Multiple Sclerosis Society

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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