Document Detail

In vivo infrared spectroscopy studies of alkanol effects on human skin.
MedLine Citation:
PMID:  18406117     Owner:  NLM     Status:  MEDLINE    
Many studies investigate the permeation of actives through the skin and ignore the role of excipients. The solvents used in formulations will undoubtedly penetrate the skin where they can have a number of effects. They can extract skin lipids, they can alter the fluidity of the lipids and they can alter the polarity of the skin. The degree to which they do this and the depth into the skin where this occurs will depend on the uptake kinetics. The problem is to distinguish the different effects. Using ATR-FTIR and deuterated materials this can be achieved in vivo. The aim of the present study was to study the higher alkanols (hexanol, octanol, decanol) in vivo using a combination of ATR-FTIR spectroscopy and tape stripping. Studies conducted in vivo using deuterated vehicles confirmed the lipid extraction effects of d-hexanol and d-octanol, whereas d-decanol did not change skin lipid content. The uptake of d-decanol was higher than for the other vehicles consistent with previous observations on mouse skin for alkanols of increasing chain length. In general, solvent uptake was proportional to the induced shift in the C-H stretching frequency. Lipid disorder was induced by all vehicles studied in vivo and was proportional to the amount of vehicle present in the skin.
M Dias; A Naik; R H Guy; J Hadgraft; M E Lane
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Publication Detail:
Type:  Journal Article     Date:  2008-02-16
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  69     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1171-5     Citation Subset:  IM    
Department of Pharmaceutics, University of London, London, UK.
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MeSH Terms
Fatty Alcohols / pharmacology*
Lipids / chemistry
Skin / chemistry*,  drug effects*
Spectrophotometry, Infrared
Spectroscopy, Fourier Transform Infrared
Reg. No./Substance:
0/Fatty Alcohols; 0/Lipids; 0/Solvents

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