Document Detail

In vivo and in vitro studies on the effect of sodium antagonists on the bladder in man and rat.
MedLine Citation:
PMID:  6312785     Owner:  NLM     Status:  MEDLINE    
The effect of oral mexiletine and intravenous lignocaine was examined in elderly patients with urinary incontinence associated with detrusor instability. Lignocaine had no demonstrable urodynamic effect in 13 patients, but 12 out of 20 patients who completed the study with mexiletine benefited, 10 becoming dry. The incidence of side-effects was high. Since there was no associated urodynamic improvement on the drug, the clinical improvement was probably secondary to the toileting regime instigated in every case. The results of the in vitro experiments on 11 rat bladders supported this contention, since mexiletine caused contractions of the preparation, and increased the rate and magnitude of spontaneous activity. Acetylcholine, histamine and 5-hydroxytryptamine receptors were not involved in these contractions.
C M Castleden; H M Duffin; E J Clarkson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Age and ageing     Volume:  12     ISSN:  0002-0729     ISO Abbreviation:  Age Ageing     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375655     Medline TA:  Age Ageing     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Ion Channels / drug effects*
Lidocaine / therapeutic use*
Mexiletine / therapeutic use*
Middle Aged
Muscle Contraction / drug effects
Propylamines / therapeutic use*
Urinary Bladder / drug effects*
Urinary Incontinence / drug therapy*
Reg. No./Substance:
0/Ion Channels; 0/Propylamines; 137-58-6/Lidocaine; 31828-71-4/Mexiletine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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