| In vivo and in vitro studies on the effect of sodium antagonists on the bladder in man and rat. | |
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MedLine Citation:
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PMID: 6312785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of oral mexiletine and intravenous lignocaine was examined in elderly patients with urinary incontinence associated with detrusor instability. Lignocaine had no demonstrable urodynamic effect in 13 patients, but 12 out of 20 patients who completed the study with mexiletine benefited, 10 becoming dry. The incidence of side-effects was high. Since there was no associated urodynamic improvement on the drug, the clinical improvement was probably secondary to the toileting regime instigated in every case. The results of the in vitro experiments on 11 rat bladders supported this contention, since mexiletine caused contractions of the preparation, and increased the rate and magnitude of spontaneous activity. Acetylcholine, histamine and 5-hydroxytryptamine receptors were not involved in these contractions. |
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Authors:
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C M Castleden; H M Duffin; E J Clarkson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Age and ageing Volume: 12 ISSN: 0002-0729 ISO Abbreviation: Age Ageing Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375655 Medline TA: Age Ageing Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 249-55 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Dose-Response Relationship, Drug Female Humans Ion Channels / drug effects* Lidocaine / therapeutic use* Male Mexiletine / therapeutic use* Middle Aged Muridae Muscle Contraction / drug effects Propylamines / therapeutic use* Urinary Bladder / drug effects* Urinary Incontinence / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 0/Propylamines; 137-58-6/Lidocaine; 31828-71-4/Mexiletine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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