Document Detail


In-vivo and in-vitro studies on the effect of amphotericin B on endothelin release.
MedLine Citation:
PMID:  1737726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since amphotericin B nephrotoxicity is mediated, in part by hypoxic tubular injury, the role of endothelin in the renal vasoconstriction, characteristic of amphotericin toxicity has been studied. Intact and salt depleted rats were infused with amphotericin B (20 micrograms/kg per min) or 5% dextrose over 20 min. Plasma endothelin levels determined at the conclusion of the infusion period, did not differ between the experimental groups, despite a marked reduction in renal blood flow noted in rats infused with amphotericin B. Amphotericin B (10(-5)-10(-7) M) did not stimulate endothelin release from cultured bovine aortic endothelial cells. However, in a model of chronic amphotericin nephrotoxicity produced by repeated daily intraperitoneal injections of amphotericin B (5 mg/kg) to salt depleted rats, renal failure was associated with elevated plasma endothelin levels (29.3 +/- 4.4 fmol/mL, vs 10.8 +/- 1.2 fmol/mL in salt depleted controls, P less than 0.01). We conclude that while plasma endothelin may be increased in chronic amphotericin B nephropathy, this peptide does not mediate the acute renal vasoconstriction associated with the infusion of this drug.
Authors:
S N Heyman; B A Clark; N Kaiser; F H Epstein; K Spokes; S Rosen; M Brezis
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  29     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  69-77     Citation Subset:  IM    
Affiliation:
Charles A. Dana Research Institute, Department of Medicine, Harvard Medical School and Beth Israel Hospital, Mass. 02215.
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MeSH Terms
Descriptor/Qualifier:
Amphotericin B / pharmacology*,  toxicity
Animals
Cattle
Cells, Cultured
Endothelins / blood,  secretion*
Kidney / drug effects
Male
Rats
Rats, Inbred Strains
Vasoconstriction / drug effects
Grant Support
ID/Acronym/Agency:
DK-39249/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Endothelins; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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