Document Detail

In-vivo and in-vitro studies on the effect of amphotericin B on endothelin release.
MedLine Citation:
PMID:  1737726     Owner:  NLM     Status:  MEDLINE    
Since amphotericin B nephrotoxicity is mediated, in part by hypoxic tubular injury, the role of endothelin in the renal vasoconstriction, characteristic of amphotericin toxicity has been studied. Intact and salt depleted rats were infused with amphotericin B (20 micrograms/kg per min) or 5% dextrose over 20 min. Plasma endothelin levels determined at the conclusion of the infusion period, did not differ between the experimental groups, despite a marked reduction in renal blood flow noted in rats infused with amphotericin B. Amphotericin B (10(-5)-10(-7) M) did not stimulate endothelin release from cultured bovine aortic endothelial cells. However, in a model of chronic amphotericin nephrotoxicity produced by repeated daily intraperitoneal injections of amphotericin B (5 mg/kg) to salt depleted rats, renal failure was associated with elevated plasma endothelin levels (29.3 +/- 4.4 fmol/mL, vs 10.8 +/- 1.2 fmol/mL in salt depleted controls, P less than 0.01). We conclude that while plasma endothelin may be increased in chronic amphotericin B nephropathy, this peptide does not mediate the acute renal vasoconstriction associated with the infusion of this drug.
S N Heyman; B A Clark; N Kaiser; F H Epstein; K Spokes; S Rosen; M Brezis
Related Documents :
11932666 - Inflammatory response in the acute phase of deep vein thrombosis.
11283846 - Altered peripheral vascular responses to exogenous and endogenous endothelin-1 in patie...
15011746 - Plasma vascular endothelial growth factor (vegf) measured in seventy dogs with spontane...
6409646 - Raised plasma levels of thromboxane b2 in systemic mastocytosis.
28196 - Urinary dopamine in man and rat: effects of inorganic salts on dopamine excretion.
15189746 - Pharmacokinetic properties and stability of continuous-infusion meropenem in adults wit...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  29     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  69-77     Citation Subset:  IM    
Charles A. Dana Research Institute, Department of Medicine, Harvard Medical School and Beth Israel Hospital, Mass. 02215.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amphotericin B / pharmacology*,  toxicity
Cells, Cultured
Endothelins / blood,  secretion*
Kidney / drug effects
Rats, Inbred Strains
Vasoconstriction / drug effects
Grant Support
Reg. No./Substance:
0/Endothelins; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multicentre study on antibiotic susceptibilities of anaerobic bacteria to cefoperazone-sulbactam and...
Next Document:  Simultaneous major depression and panic disorder: treatment with electroconvulsive therapy.