| In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine at Indian Oil Corporation, Mathura (U.P.). | |
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MedLine Citation:
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PMID: 8319813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vivo and in vitro susceptibility of Plasmodium falciparum to chloroquine were conducted at Indian Oil Corporation (IOC), Mathura, India. 18 out of 31 cases showed resistance [minimum inhibitory concentration (MIC) 8 pmol] in in vitro study. EC50 and EC90 values estimated from log-probit analysis for resistant isolates were 0.66 and 1.44 microM/litre, and for sensitive isolates 0.28 and 0.96 microM/litre blood respectively. In vivo tests identified 13 cases (40.62%) as resistant and 19 cases (59.73%) as sensitive out of 32 cases. All the cases belonged to IOC, Mathura complex, or its vicinity. |
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Authors:
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V K Dua; P K Kar; S Kumar; V P Sharma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of malariology Volume: 30 ISSN: 0367-8326 ISO Abbreviation: Indian J Malariol Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-08-05 Completed Date: 1993-08-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 17540010R Medline TA: Indian J Malariol Country: INDIA |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM |
Affiliation:
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Malaria Research Centre (Field Station), BHEL Complex, Ranipur, Hardwar, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chloroquine / pharmacology*, therapeutic use* Dose-Response Relationship, Drug Drug Resistance Humans India Malaria, Falciparum / drug therapy* Plasmodium falciparum / drug effects*, growth & development |
| Chemical | |
Reg. No./Substance:
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54-05-7/Chloroquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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