Document Detail

In vivo and in vitro influence of human recombinant hemoglobin on esophageal function.
MedLine Citation:
PMID:  7900805     Owner:  NLM     Status:  MEDLINE    
The purpose of the present investigation was to examine the influence of a nitric oxide scavenger, hemoglobin (Hb), on esophageal function. Intraluminal pressures of anesthetized opossums were recorded from lower esophageal sphincter (LES) and 1, 5, and 9 cm above the LES. The influence of a representative Hb-based oxygen carrier was examined on swallowing-induced esophageal peristalsis and LES relaxation. In in vitro studies, LES relaxation and esophageal peristaltic contractions were induced by the activation of nonadrenergic noncholinergic (NANC) neurons by electrical field stimulation (EFS). Hb caused significant impairment in swallowing- and EFS-induced LES relaxation and a significant increase in the speed of esophageal peristalsis. In some experiments, swallowing caused simultaneous contractions in the esophagus following Hb administration. Although Hb completely blocked LES relaxation by NO and significantly attenuated that by NANC nerve stimulation, it had no significant effect on isoproterenol-induced LES relaxations. The data support the role of NO in LES relaxation and esophageal peristalsis. This esophageal model may be important in understanding the influence of NO inhibitors and scavengers in gastrointestinal motility.
S Chakder; G J Rosenthal; S Rattan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G443-50     Citation Subset:  IM    
Thomas Jefferson University, Department of Medicine, Philadelphia, Pennsylvania 19107.
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MeSH Terms
Deglutition / physiology
Electric Stimulation
Esophagogastric Junction / drug effects,  physiology
Esophagus / drug effects*,  physiology*
Hemoglobins / pharmacology*
Isoproterenol / pharmacology
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Neurotransmitter Agents / physiology
Nitric Oxide / antagonists & inhibitors,  metabolism
Peristalsis / drug effects
Recombinant Proteins / pharmacology
Grant Support
Reg. No./Substance:
0/Hemoglobins; 0/Neurotransmitter Agents; 0/Recombinant Proteins; 10102-43-9/Nitric Oxide; 7683-59-2/Isoproterenol

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