Document Detail


In vivo and in vitro effects of magnesium sulfate in the cerebrovascular bed of the goat.
MedLine Citation:
PMID:  1957890     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of magnesium sulfate in the cerebrovascular bed were studied both in vivo, by measuring cerebral blood flow in conscious nonpregnant goats, and in vitro, by recording isometric tension in isolated goat middle cerebral arteries. Injections of increasing doses (10 to 300 mg) of magnesium sulfate directly into the cerebral circulation elicited transient and dose-dependent increases in cerebral blood flow and decreases in cerebral vascular resistance. Similar results were obtained when increasing doses (0.3 to 3 gm/15 min) of magnesium sulfate were infused intravenously, although the vasodilatations reached a stable plateau that remained when the infusions finished. Cumulative addition of magnesium sulfate (10(-5) to 3 x 10(-2) mol/L) did not change the isometric tension of isolated arterial segments at resting tone, but relaxed in a concentration-dependent manner the arterial segments preconstricted with 10(-5) mol/L prostaglandin F2 alpha. These results demonstrate that magnesium sulfate acts as a dilator in the cerebral circulation by acting directly on the cerebral arteries. This could explain, at least in part, its beneficial effects on preeclampsia-eclampsia.
Authors:
A J Perales; G Torregrosa; J B Salom; F J Miranda; J A Alabadí; J Monleón; E Alborch
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  165     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-27     Completed Date:  1991-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1534-8     Citation Subset:  AIM; IM    
Affiliation:
Hospital Maternal, Universidad de Valencia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cerebral Arteries / drug effects
Cerebrovascular Circulation / drug effects*
Dose-Response Relationship, Drug
Female
Goats
Heart Rate / drug effects
Infusions, Intravenous
Injections, Intra-Arterial
Isometric Contraction / drug effects
Magnesium Sulfate / pharmacology*
Time Factors
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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