| In vivo and in vitro effects of magnesium sulfate in the cerebrovascular bed of the goat. | |
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MedLine Citation:
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PMID: 1957890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of magnesium sulfate in the cerebrovascular bed were studied both in vivo, by measuring cerebral blood flow in conscious nonpregnant goats, and in vitro, by recording isometric tension in isolated goat middle cerebral arteries. Injections of increasing doses (10 to 300 mg) of magnesium sulfate directly into the cerebral circulation elicited transient and dose-dependent increases in cerebral blood flow and decreases in cerebral vascular resistance. Similar results were obtained when increasing doses (0.3 to 3 gm/15 min) of magnesium sulfate were infused intravenously, although the vasodilatations reached a stable plateau that remained when the infusions finished. Cumulative addition of magnesium sulfate (10(-5) to 3 x 10(-2) mol/L) did not change the isometric tension of isolated arterial segments at resting tone, but relaxed in a concentration-dependent manner the arterial segments preconstricted with 10(-5) mol/L prostaglandin F2 alpha. These results demonstrate that magnesium sulfate acts as a dilator in the cerebral circulation by acting directly on the cerebral arteries. This could explain, at least in part, its beneficial effects on preeclampsia-eclampsia. |
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Authors:
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A J Perales; G Torregrosa; J B Salom; F J Miranda; J A Alabadí; J Monleón; E Alborch |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 165 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1991-12-27 Completed Date: 1991-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1534-8 Citation Subset: AIM; IM |
Affiliation:
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Hospital Maternal, Universidad de Valencia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cerebral Arteries / drug effects Cerebrovascular Circulation / drug effects* Dose-Response Relationship, Drug Female Goats Heart Rate / drug effects Infusions, Intravenous Injections, Intra-Arterial Isometric Contraction / drug effects Magnesium Sulfate / pharmacology* Time Factors Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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