| In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N-acetyl procainamide. | |
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MedLine Citation:
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PMID: 6164783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effects of N-acetyl procainamide (NAPA) on isolated canine cardiac tissues by using standard microelectrode techniques. NAPA (10-40 mg/l) does not suppress the rate of phase 4 depolarization of Purkinje fibers and does not change resting membrane potential, action potential amplitude or maximum upstroke velocity of phase O of the action potentials of Purkinje fibers or ventricular muscle cells. In contrast, action potential duration of both types of cells is significantly prolonged by NAPA in a dose-dependent manner. In toxic concentrations (80-240 mg/l), NAPA can produce a "secondary plateau" at about -55 mV during phase 3 of the action potential of Purkinje fibers driven at cycle lengths of 2000 to 4000 msec. Early afterdepolarizations and single or multiple spontaneous action potentials were often triggered during the secondary plateau. When NAPA is given to conscious or anesthetized dogs (50-100 mg/kg i.v.), ventricular extrasystoles occur at constant coupling intervals if the basic rate of ventricular activation is slow (60 per minute or slower). Single extrasystoles, or the first extrasystole in a salvo, appear at coupling intervals of 400 to 600 msec. The single and multiple extrasystoles induced by NAPA may be caused by action potentials triggered during the secondary plateau and may degenerate into ventricular fibrillation. In doses of up to 100 mg/kg i.v., NAPA exerts slight antiarrhythmic effects in dogs with 24-hr myocardial infarcts. |
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Authors:
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K H Dangman; B F Hoffman |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 217 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1981 Jun |
Date Detail:
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Created Date: 1981-07-23 Completed Date: 1981-07-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 851-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acecainide
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pharmacology* Action Potentials / drug effects Animals Anti-Arrhythmia Agents* Arrhythmias, Cardiac / chemically induced* Coronary Vessels / physiology Dogs Heart Block / physiopathology Heart Rate / drug effects Heart Ventricles / drug effects Ligation Membrane Potentials / drug effects Procainamide / analogs & derivatives* Purkinje Fibers / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-08508/HL/NHLBI NIH HHS; HL-12738/HL/NHLBI NIH HHS; HL24354/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 32795-44-1/Acecainide; 51-06-9/Procainamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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