| In vivo imaging of dopaminergic neurotransmission after transient focal ischemia in rats. | |
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MedLine Citation:
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PMID: 23149560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The precise biologic mechanisms involved in functional recovery processes in response to stroke such as dopaminergic neurotransmission are still largely unknown. For this purpose, we performed in parallel in vivo magnetic resonance imaging and positron emission tomography (PET) with [(18)F]fluorodeoxyglucose ([(18)F]FDG) and [(11)C]raclopride at 1, 3, 7, 14, 21, and 28 days after middle cerebral artery occlusion in rats. In the ischemic territory, PET [(18)F]FDG showed a initial decrease in cerebral metabolism followed by a time-dependent recovery to quasi-normal values at day 14 after ischemia. The PET with [(11)C]raclopride, a ligand for dopamine D(2) receptor, showed a sustained binding during the first week after ischemia that declined dramatically from day 14 to day 28. Interestingly, a slight increase in [(11)C]raclopride binding was observed at days 1 to 3 followed by the uppermost binding at day 7 in the contralateral territory. Likewise, in vitro autoradiography using [(3)H]raclopride confirmed these in vivo results. Finally, the neurologic test showed major neurologic impairment at day 1 followed by a recovery of the cerebral function at day 28 after cerebral ischemia. Taken together, these results might suggest that dopamine D(2) receptor changes in the contralateral hemisphere could have a key role in functional recovery after cerebral ischemia. |
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Authors:
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Abraham Martín; Vanessa Gómez-Vallejo; Eneko San Sebastián; Daniel Padró; Irati Markuerkiaga; Irantzu Llarena; Jordi Llop |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-11-14 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 33 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-01 Completed Date: 2013-03-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 244-52 Citation Subset: IM |
Affiliation:
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Molecular Imaging Unit, CIC biomaGUNE, San Sebastián, Spain. amartin@cicbiomagune.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / metabolism*, radiography Dopamine Antagonists / pharmacology Dopaminergic Neurons / metabolism*, pathology Fluorodeoxyglucose F18 / pharmacology Infarction, Middle Cerebral Artery / metabolism, radiography Male Positron-Emission Tomography Raclopride / pharmacology Radiopharmaceuticals / pharmacology Rats Rats, Sprague-Dawley Receptors, Dopamine D2 Stroke / metabolism*, radiography Synaptic Transmission* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Antagonists; 0/Radiopharmaceuticals; 0/Receptors, Dopamine D2; 63503-12-8/Fluorodeoxyglucose F18; 84225-95-6/Raclopride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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