| In vivo hyporesponsiveness induced by Sendai virus in CFLP mice. | |
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MedLine Citation:
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PMID: 6183956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sendai and Semliki Forest viruses (SFV) raised the interferon (IFN) level in blood and suppressed the acute inflammatory response induced by carrageenan in CFLP mice. After Sendai virus had been inoculated, unresponsiveness developed to repeated challenge either with the same virus or with SFV. The hyporeactive state culminated 48 hr after first virus inoculation. It was characterized (1) by absence of IFN induction and (2) by disappearance of the virus-induced anti-inflammatory effect. In contrast, the anti-inflammatory effect of indomethacin and dexamethasone remained unchanged. In addition, peripheral white blood cells were counted upon Sendai virus inoculation either in normal or in hyporesponsive mice. Six hr after inoculation, Sendai virus induced a marked granulocytosis with lymphopenia. In hyporesponsive mice leukocytosis was observed. Repeated Sendai virus injection was followed by a less pronounced granulocytosis, while the decreased number of mononuclear cells remained unchanged. These alterations in mice inoculated with Sendai virus offers a model of hyporesponsiveness established in vivo. |
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Authors:
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I Mécs; M Koltai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta virologica Volume: 26 ISSN: 0001-723X ISO Abbreviation: Acta Virol. Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1983-01-19 Completed Date: 1983-01-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370401 Medline TA: Acta Virol Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 346-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrageenan / pharmacology Female Granulocytes Immune Tolerance* Inflammation / immunology* Interferons / biosynthesis Leukocyte Count Mice Mice, Inbred Strains Parainfluenza Virus 1, Human / immunology* Semliki forest virus / immunology Serotonin / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 9000-07-1/Carrageenan; 9008-11-1/Interferons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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