Document Detail


In vivo hydrogen-1 magnetic resonance spectroscopy study of human intracranial tumors.
MedLine Citation:
PMID:  10322655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the metabolic changes, pathological state and histological types of intracranial tumors with hydrogen-1 magnetic resonance spectroscopy (H-1 MRS). METHODS: Thirteen patients with intracranial tumors were studied with localized proton magnetic resonance spectroscopy (H-1MRS), in vivo. All spectra were obtained with a 2.0 T whole body MR imaging system. RESULTS: All the spectra of these tumors exhibited high ratios of choline (Cho)/creatine (Cr) and Cho/N-acetyl aspartate (NAA), and histologically different tumors showed obvious variations in the metabolite ratios. Significant differences of Cho/Cr ratio were found between meningiomas and astrocytomas by statistical evaluation. The spectra obtained after operation were remarkably different from those before operation. CONCLUSION: H-1 MRS can serve as a non-invasive clinical test for therapeutic and prognostic uses for intracranial tumors.
Authors:
W Luan; J Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  111     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1999-06-29     Completed Date:  1999-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  56-8     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, People's Hospital of Beijing Medical University, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Astrocytoma / metabolism*
Brain / metabolism
Brain Neoplasms / metabolism*
Choline / metabolism
Creatine / metabolism
Female
Humans
Magnetic Resonance Spectroscopy / diagnostic use
Male
Meningeal Neoplasms / metabolism*
Meningioma / metabolism*
Middle Aged
Chemical
Reg. No./Substance:
57-00-1/Creatine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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