Document Detail

In vivo functional evaluation of central cholinergic circuits in vascular dementia.
MedLine Citation:
PMID:  18829384     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Central cholinergic circuits of human brain can be tested non-invasively by coupling peripheral nerve stimulation with transcranial magnetic stimulation of motor cortex. This test, named short latency afferent inhibition (SAI) has been shown in healthy subjects to be sensitive to the blockage of muscarinic acetylcholine receptors and it is impaired in Alzheimer disease (AD) patients, a cholinergic form of dementia, while it is normal in non-cholinergic forms of dementia such as fronto-temporal dementia. The objective of present study was to evaluate central cholinergic circuits in patients with Vascular Dementia (VaD). METHODS: We evaluated SAI in a group of patients with VaD and compared the data with those from a group of AD patients and a control group of age-matched healthy individuals. RESULTS: Mean SAI was normal in VaD patients while it was significantly reduced in AD patients. The analysis of individual data showed abnormal SAI in 75% of AD and in only 25% of VaD. CONCLUSIONS: SAI is normal in most of VaD patients in contrast with AD patients. This test might be used for the functional evaluation of central cholinergic circuits in VaD patients. SIGNIFICANCE: SAI testing may represent a useful additional tool for the evaluation of patients with VaD however, further studies are required in order to evaluate whether this method can be used for the differential diagnosis between pure VaD and different forms of dementia.
V Di Lazzaro; F Pilato; M Dileone; P Profice; C Marra; F Ranieri; D Quaranta; G Gainotti; P A Tonali
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Publication Detail:
Type:  Journal Article     Date:  2008-10-01
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  119     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2494-500     Citation Subset:  IM    
Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168 Rome, Italy.
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MeSH Terms
Acetylcholine / physiology*
Aged, 80 and over
Analysis of Variance
Brain / metabolism*,  pathology
Case-Control Studies
Dementia, Vascular / pathology*,  physiopathology*
Evaluation Studies as Topic
Evoked Potentials, Motor / drug effects,  physiology,  radiation effects
Follow-Up Studies
Nerve Net / pathology
Neural Inhibition / drug effects,  physiology,  radiation effects
Neuropsychological Tests
Reaction Time / drug effects,  physiology,  radiation effects
Transcranial Magnetic Stimulation / methods
Reg. No./Substance:

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