| In vivo functional brain imaging and a therapeutic trial of l-arginine in MELAS patients. | |
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MedLine Citation:
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PMID: 21600268 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is the most common type of mitochondrial disease and is characterized by stroke-like episodes (SEs), myopathy, lactic acidosis, diabetes mellitus, hearing-loss and cardiomyopathy. The causal hypotheses for SEs in MELAS presented to date are angiopathy, cytopathy and neuronal hyperexcitability. l-arginine (Arg) has been applied for the therapy in MELAS patients. METHODS: Recent advanced in vivo imaging techniques such as MRI, MRS and PET were applied for evaluating the pathogenesis of SEs (i.e. angiopathy and cytopathy) and monitoring the biochemical effects of l-Arg. RESULTS: Administration of l-Arg to MELAS patients has been successful in reducing neurological symptoms due to acute strokes and preventing recurrences of SEs in the chronic phase. l-Arg has dual pharmaceutical effects on both angiopathy and cytopathy in MELAS. CONCLUSIONS: In vivo functional brain imaging promotes a better understanding of the pathogenesis and potential therapies for MELAS patients. This article is part of a Special Issue entitled Biochemistry of Mitochondria, Life and Intervention 2010. |
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Authors:
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Makoto Yoneda; Masamichi Ikawa; Kenichiro Arakawa; Takashi Kudo; Hirohiko Kimura; Yasuhisa Fujibayashi; Hidehiko Okazawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-8 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: - ISSN: 0006-3002 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Department of Neurology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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