| In vivo function tests of the effect of tilorone and niridazole on cell-mediated immunity in chickens. | |
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MedLine Citation:
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PMID: 23063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The need for effective, safe, specific cellular immune suppression in avian research led to the study of effects of tilorone and niridazole on cell-mediated immunity of chickens. Two in vivo tests for cell-mediated immunity function were used--the graft-vs-host (GvH) test and the delayed hypersensitivity (DH) test. Humoral immunity was evaluated by measuring natural hemagglutination (HA) titers against rabbit red blood cells. Intraperitoneal administration of tilorone to young chickens appeared to have severe toxic side effects and was of little value as an immune suppressant. Oral administration of tilorone to 6-week-old chickens caused DH suppression, but no marked effect was seen on GvH reactions or HA titers. Toxicosis appeared less severe. Oral administration of niridazole to 6-week-old birds caused nearly complete loss of GvH and DH reactivity but caused an increase in HA titers. General toxic effects of niridazole were not apparent. |
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Authors:
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J P Donahoe; J Giambrone; O J Fletcher; S H Kleven |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of veterinary research Volume: 38 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1977 Dec |
Date Detail:
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Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2013-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens / immunology* Fluorenes / pharmacology* Graft vs Host Reaction / drug effects Hemagglutination Tests Immunity, Cellular / drug effects* Male Niridazole / pharmacology* Tilorone / pharmacology* Tuberculin Test |
| Chemical | |
Reg. No./Substance:
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0/Fluorenes; 27591-97-5/Tilorone; 61-57-4/Niridazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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