Document Detail


In vivo function tests of the effect of tilorone and niridazole on cell-mediated immunity in chickens.
MedLine Citation:
PMID:  23063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The need for effective, safe, specific cellular immune suppression in avian research led to the study of effects of tilorone and niridazole on cell-mediated immunity of chickens. Two in vivo tests for cell-mediated immunity function were used--the graft-vs-host (GvH) test and the delayed hypersensitivity (DH) test. Humoral immunity was evaluated by measuring natural hemagglutination (HA) titers against rabbit red blood cells. Intraperitoneal administration of tilorone to young chickens appeared to have severe toxic side effects and was of little value as an immune suppressant. Oral administration of tilorone to 6-week-old chickens caused DH suppression, but no marked effect was seen on GvH reactions or HA titers. Toxicosis appeared less severe. Oral administration of niridazole to 6-week-old birds caused nearly complete loss of GvH and DH reactivity but caused an increase in HA titers. General toxic effects of niridazole were not apparent.
Authors:
J P Donahoe; J Giambrone; O J Fletcher; S H Kleven
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of veterinary research     Volume:  38     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2013-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chickens / immunology*
Fluorenes / pharmacology*
Graft vs Host Reaction / drug effects
Hemagglutination Tests
Immunity, Cellular / drug effects*
Male
Niridazole / pharmacology*
Tilorone / pharmacology*
Tuberculin Test
Chemical
Reg. No./Substance:
0/Fluorenes; 27591-97-5/Tilorone; 61-57-4/Niridazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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