Document Detail

In vivo fluence rate effect in photodynamic therapy of early cancers with tetra(m-hydroxyphenyl)chlorin.
MedLine Citation:
PMID:  8972639     Owner:  NLM     Status:  MEDLINE    
Several parameters affect clinical trials in photodynamic therapy and influence the therapeutic outcome. Beside drug dose, light dose, drug-light interval and other variables, the fluence rate is a parameter that can influence the therapeutic results. In this study we have evaluated the fluence rate effect with a second-generation photosensitizer, tetra(m-hydroxyphenyl)chlorin (mTHPC) using a 7,12-dimethylbenz(a)anthracene induced early squamous cell carcinoma of the Syrian hamster cheek pouch as a tumor model. Following injection of 0.5 mg/kg of mTHPC, irradiation tests were performed at two drug-light intervals, 4 and 8 days. Wavelength and light dose were adapted from those applied routinely in clinical trials. Irradiations at 652 nm were carried out with fluences ranging from 8 to 20 J/cm2 delivered at fluence rates of 15 and 150 mW/cm2. Similar tests were also performed at 514 nm with a fluence of 80 J/cm2 delivered at fluence rates ranging from 25 to 125 mW/cm2. At both wavelengths and drug-light intervals for a given fluence, the higher fluence rates resulted in less tissue damage in tumor and healthy mucosae. However, the lower fluence rates yielded slightly less therapeutic selectivity. This study confirms that the fluence rate is of major importance in clinical PDT.
S A Blant; A Woodtli; G Wagnières; C Fontolliet; H van den Bergh; P Monnier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  64     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-22     Completed Date:  1997-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  963-8     Citation Subset:  IM    
Department of Otolaryngology Head and Neck Surgery, CHUV Hospital, Lausanne, Switzerland.
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MeSH Terms
Carcinoma, Squamous Cell / drug therapy*
Mesoporphyrins / therapeutic use*
Mouth Neoplasms / drug therapy*
Neoplasms, Experimental / drug therapy*
Radiation-Sensitizing Agents / therapeutic use*
Reg. No./Substance:
0/Mesoporphyrins; 0/Radiation-Sensitizing Agents; 0/temoporfin

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