| In vivo fiber tractography using DT-MRI data. | |
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MedLine Citation:
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PMID: 11025519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fiber tract trajectories in coherently organized brain white matter pathways were computed from in vivo diffusion tensor magnetic resonance imaging (DT-MRI) data. First, a continuous diffusion tensor field is constructed from this discrete, noisy, measured DT-MRI data. Then a Frenet equation, describing the evolution of a fiber tract, was solved. This approach was validated using synthesized, noisy DT-MRI data. Corpus callosum and pyramidal tract trajectories were constructed and found to be consistent with known anatomy. The method's reliability, however, degrades where the distribution of fiber tract directions is nonuniform. Moreover, background noise in diffusion-weighted MRIs can cause a computed trajectory to hop from tract to tract. Still, this method can provide quantitative information with which to visualize and study connectivity and continuity of neural pathways in the central and peripheral nervous systems in vivo, and holds promise for elucidating architectural features in other fibrous tissues and ordered media. |
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Authors:
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P J Basser; S Pajevic; C Pierpaoli; J Duda; A Aldroubi |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 44 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-03 Completed Date: 2000-11-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 625-32 Citation Subset: IM |
Affiliation:
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Section on Tissue Biophysics and Biomimetics, NICHD, Bethesda, Maryland 20892-5772, USA. pjbasser@helix.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts Brain / anatomy & histology* Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging* / methods Nerve Fibers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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