Document Detail


In vivo fate tracing studies of mammalian taste cell progenitors.
MedLine Citation:
PMID:  19686103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In mammals, the homogeneous lingual epithelium in the process of development forms specialized placodal cells that undergo a series of morphogenetic changes to form a papilla. Taste buds appear in the papillary epithelium around birth and thus papillae serve to house the taste buds in the adult. However, evidence for a precise lineage relationship between a putative embryonic taste progenitor population and functional adult taste buds has so far been elusive and is primarily indirect. Also, mammalian taste papillae are reminiscent of epithelial appendages suggesting that the mesenchymal tissue of the papillae could be involved in the formation of these lingual structures. These major questions in the field of mammalian taste development have remained unanswered due to lack of fate mapping studies that would label embryonic cell populations and remain indelibly marked in the adult. Taking advantage of a genetic fate mapping approach to label cell populations both in the lingual epithelium and mesenchyme and following their fate during development would be an ideal way to assess each of these tissues contribution in taste bud formation. Fate mapping studies using tissue specific cre strains crossed with reporter alleles would uncover unique features in the formation of these specialized sensory cells and also provide us with an in vivo model system for taste organ specific experimental manipulations during development.
Authors:
Shoba Thirumangalathu; Linda A Barlow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1170     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-09-25     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology and the Rocky Mountain Taste & Smell Center, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA. shoba.thirumangalathu@ucdenver.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Lineage
Mammals
Stem Cells / cytology*
Taste Buds / cytology*,  embryology
Grant Support
ID/Acronym/Agency:
DC004657/DC/NIDCD NIH HHS; DC008373/DC/NIDCD NIH HHS; R01 DC008373-03/DC/NIDCD NIH HHS
Comments/Corrections

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