Document Detail

In vivo evidence that L-S-nitrosocysteine may exert its vasodilator effects by interaction with thiol residues in the vasculature.
MedLine Citation:
PMID:  10611438     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of the lipophobic thiol chelator, para-hydroxymercurobenzoic acid (25 and 50 micromol/kg, i.v.) on the falls in mean arterial blood pressure and regional vascular resistances produced by L-S-nitrosocysteine (400 nmol/kg, i.v.) and the nitric oxide (NO)-donors, (Z)-1-&z. sfnc;N-methyl-N-[6(N-methylammoniohexyl)amino]&z.sfnc; diazen-1-ium-1, 2-diolate (MAHMA NONOate, 25 nmol/kg, i.v.) and sodium nitroprusside (10 microg/kg, i.v.), in urethane-anesthetized rats. The L-S-nitrosocysteine-induced responses were markedly diminished whereas the MAHMA NONOate- and sodium nitroprusside-induced responses were minimally affected by para-hydroxymercurobenzoic acid. These results suggest that the vasodilator actions of L-S-nitrosocysteine involves the interaction with membrane thiols in vascular smooth muscle of resistance arteries and that para-hydroxymercurobenzoic acid does not markedly affect NO-mediated vasodilation.
A Hoque; J N Bates; S J Lewis
Related Documents :
2402588 - Effects of cholecystokinin and cholinergic receptor blockade on guinea pig pepsinogen s...
2103898 - Composition of amino acid infusions and effect of cholecystokinin on insulin release in...
3356358 - Acid stimulated alkaline secretion in the rabbit duodenum is passive and correlates wit...
3924748 - Effect of omeprazole on the secretion of intrinsic factor, gastric acid and pepsin in man.
16910718 - Quantitation of the main constituents of some authentic sesame seed oils of different o...
1653678 - Tooth surface loss and exposure to organic and inorganic acid fumes in workplace air.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  384     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
The Department of Pharmacology, University of Iowa, IA 52242, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Vessels / drug effects*,  physiology
Cysteine / analogs & derivatives*,  metabolism,  pharmacology
Hemodynamics / drug effects
Hydrazines / pharmacology
Hydroxymercuribenzoates / pharmacology
Nitroprusside / pharmacology
Nitroso Compounds / metabolism,  pharmacology*
Rats, Sprague-Dawley
Sulfhydryl Compounds / metabolism*
Vasodilation / drug effects*
Vasodilator Agents / metabolism,  pharmacology
Grant Support
Reg. No./Substance:
0/1-hexanamine-6-(2-hydroxy-1-methyl-2-nitrosohydrazine)-N-methyl; 0/Hydrazines; 0/Hydroxymercuribenzoates; 0/Nitroso Compounds; 0/S-Nitrosothiols; 0/Sulfhydryl Compounds; 0/Vasodilator Agents; 138-85-2/4-hydroxymercuribenzoate; 15078-28-1/Nitroprusside; 51209-75-7/S-nitrosocysteine; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Basal inhibitory action of endogenous endothelin on the sympathetic contraction in the isolated rat ...
Next Document:  Effect of non-peptide tachykinin NK(1) receptor antagonists on non-adrenergic, non-cholinergic neuro...