Document Detail


In vivo evidence that L-S-nitrosocysteine may exert its vasodilator effects by interaction with thiol residues in the vasculature.
MedLine Citation:
PMID:  10611438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effects of the lipophobic thiol chelator, para-hydroxymercurobenzoic acid (25 and 50 micromol/kg, i.v.) on the falls in mean arterial blood pressure and regional vascular resistances produced by L-S-nitrosocysteine (400 nmol/kg, i.v.) and the nitric oxide (NO)-donors, (Z)-1-&z. sfnc;N-methyl-N-[6(N-methylammoniohexyl)amino]&z.sfnc; diazen-1-ium-1, 2-diolate (MAHMA NONOate, 25 nmol/kg, i.v.) and sodium nitroprusside (10 microg/kg, i.v.), in urethane-anesthetized rats. The L-S-nitrosocysteine-induced responses were markedly diminished whereas the MAHMA NONOate- and sodium nitroprusside-induced responses were minimally affected by para-hydroxymercurobenzoic acid. These results suggest that the vasodilator actions of L-S-nitrosocysteine involves the interaction with membrane thiols in vascular smooth muscle of resistance arteries and that para-hydroxymercurobenzoic acid does not markedly affect NO-mediated vasodilation.
Authors:
A Hoque; J N Bates; S J Lewis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  384     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Affiliation:
The Department of Pharmacology, University of Iowa, IA 52242, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessels / drug effects*,  physiology
Cysteine / analogs & derivatives*,  metabolism,  pharmacology
Hemodynamics / drug effects
Hydrazines / pharmacology
Hydroxymercuribenzoates / pharmacology
Male
Nitroprusside / pharmacology
Nitroso Compounds / metabolism,  pharmacology*
Rats
Rats, Sprague-Dawley
S-Nitrosothiols*
Sulfhydryl Compounds / metabolism*
Vasodilation / drug effects*
Vasodilator Agents / metabolism,  pharmacology
Grant Support
ID/Acronym/Agency:
HL-14388/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/1-hexanamine-6-(2-hydroxy-1-methyl-2-nitrosohydrazine)-N-methyl; 0/Hydrazines; 0/Hydroxymercuribenzoates; 0/Nitroso Compounds; 0/S-Nitrosothiols; 0/Sulfhydryl Compounds; 0/Vasodilator Agents; 138-85-2/4-hydroxymercuribenzoate; 15078-28-1/Nitroprusside; 51209-75-7/S-nitrosocysteine; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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